Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
Objective: To explore the effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological analysis. Methods: TCMSP platform was used to search the compounds of Sini Decoction plus Ginseng with oral bioavailability（OB）≥30% and druglikeness（ DL）≥0.18，and the results were input in...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Editorial Board of Journal of Hainan Medical University
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b42e6f20a51c414c82f98e868de72d37 |
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| Sumario: | Objective: To explore the effect of Sini Decoction plus Ginseng on COVID-19 based on
network pharmacological analysis. Methods: TCMSP platform was used to search the
compounds of Sini Decoction plus Ginseng with oral bioavailability（OB）≥30% and druglikeness（
DL）≥0.18，and the results were input into the UniProt database and converted into
standard target names；Genecards and OMIM database were used to find COVID-19 target,
and the intersection targets were obtained and Venn diagram was drawn. Cytoscape 3.7.2 was
applied to make the network diagram of composition-disease-target；The interaction database
platform-String was used to analyze the target protein interaction, and the data were input
into the software of Cytoscape 3.7.2 to make the network diagram；David database was used
to analyze the accumulation of Gene Ontology（GO）and Kyoto Encyclopedia of Genes and
Genomes（KEGG）signaling pathways of drug-disease intersection targets. The component
target pathway network was constructed by using Cytoscape 3.7.2. Results: Altogether, 112
active components of Sini Decoction plus Ginseng were screened, corresponding to 234
targets. Besides, 261 COVID-19 targets were obtained after screening, and the Venn map
showed that 50 targets were intersected. Quercetin, kaempferol，naringenin，and β-sitosterol
were found to have higher moderate values shown by the component-disease-target network.
The target proteins with high PPI network analysis value were IL-6，MAPK8，MAPK3，
MAPK1，TP53，TNF，and CASP3. GO enrichment function analysis showed that 341
biological processes, 33 cell components，and 50 molecular functions were involved，which
showed inflammatory reaction，cell response to lipopolysaccharide，exogenous apoptosis
signal pathway，positive regulation of RNA polymerase Ⅱ promoter transcription，cytokine
activity，chemokine activity，heme binding，and other biological processes. KEGG
signaling pathway enrichment function analysisshowed that there were 112 signaling pathways.
It included TNF signaling pathway，tuberculosis，influenza A，PI3K Akt signaling
pathway，HIF-1 signaling pathway，and Toll-like receptor signaling pathway. According
to the component-target-pathway network diagram，quercetin，kaempferol，naringenin，
and β -sitosterol in Sini Decoction plus Ginseng may act on IL-6，MAPK8， MAPK3，
MAPK1，TP53，TNF，CASP3，and other targets through TNF signaling pathway，MAPK
signaling pathway，Tolllike receptor signaling pathway，PI3K-Akt signaling pathway，and
HIF-1 signaling pathway. Conclusion：Sini Decoction plus Ginseng can affect COVID-19
through multiple active components，multiple targets，and multiple pathways. |
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