Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an

Objective: To explore the effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological analysis. Methods: TCMSP platform was used to search the compounds of Sini Decoction plus Ginseng with oral bioavailability（OB）≥30% and druglikeness（ DL）≥0.18，and the results were input in...

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Autores principales:	Xin-Hua Zhao, Song-Jiang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	covid-19 network pharmacology sini decoction plus ginseng mechanism of action Medicine R
Acceso en línea:	https://doaj.org/article/b42e6f20a51c414c82f98e868de72d37
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spelling	oai:doaj.org-article:b42e6f20a51c414c82f98e868de72d372021-11-16T01:18:52ZEffect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an1007-1237https://doaj.org/article/b42e6f20a51c414c82f98e868de72d372021-09-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202119/01.pdfhttps://doaj.org/toc/1007-1237Objective: To explore the effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological analysis. Methods: TCMSP platform was used to search the compounds of Sini Decoction plus Ginseng with oral bioavailability（OB）≥30% and druglikeness（ DL）≥0.18，and the results were input into the UniProt database and converted into standard target names；Genecards and OMIM database were used to find COVID-19 target, and the intersection targets were obtained and Venn diagram was drawn. Cytoscape 3.7.2 was applied to make the network diagram of composition-disease-target；The interaction database platform-String was used to analyze the target protein interaction, and the data were input into the software of Cytoscape 3.7.2 to make the network diagram；David database was used to analyze the accumulation of Gene Ontology（GO）and Kyoto Encyclopedia of Genes and Genomes（KEGG）signaling pathways of drug-disease intersection targets. The component target pathway network was constructed by using Cytoscape 3.7.2. Results: Altogether, 112 active components of Sini Decoction plus Ginseng were screened, corresponding to 234 targets. Besides, 261 COVID-19 targets were obtained after screening, and the Venn map showed that 50 targets were intersected. Quercetin, kaempferol，naringenin，and β-sitosterol were found to have higher moderate values shown by the component-disease-target network. The target proteins with high PPI network analysis value were IL-6，MAPK8，MAPK3， MAPK1，TP53，TNF，and CASP3. GO enrichment function analysis showed that 341 biological processes, 33 cell components，and 50 molecular functions were involved，which showed inflammatory reaction，cell response to lipopolysaccharide，exogenous apoptosis signal pathway，positive regulation of RNA polymerase Ⅱ promoter transcription，cytokine activity，chemokine activity，heme binding，and other biological processes. KEGG signaling pathway enrichment function analysisshowed that there were 112 signaling pathways. It included TNF signaling pathway，tuberculosis，influenza A，PI3K Akt signaling pathway，HIF-1 signaling pathway，and Toll-like receptor signaling pathway. According to the component-target-pathway network diagram，quercetin，kaempferol，naringenin， and β -sitosterol in Sini Decoction plus Ginseng may act on IL-6，MAPK8， MAPK3， MAPK1，TP53，TNF，CASP3，and other targets through TNF signaling pathway，MAPK signaling pathway，Tolllike receptor signaling pathway，PI3K-Akt signaling pathway，and HIF-1 signaling pathway. Conclusion：Sini Decoction plus Ginseng can affect COVID-19 through multiple active components，multiple targets，and multiple pathways.Xin-Hua ZhaoSong-Jiang LiuEditorial Board of Journal of Hainan Medical Universityarticlecovid-19network pharmacologysini decoction plus ginsengmechanism of actionMedicineRENJournal of Hainan Medical University, Vol 27, Iss 19, Pp 1-1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 network pharmacology sini decoction plus ginseng mechanism of action Medicine R
spellingShingle	covid-19 network pharmacology sini decoction plus ginseng mechanism of action Medicine R Xin-Hua Zhao Song-Jiang Liu Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
description	Objective: To explore the effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological analysis. Methods: TCMSP platform was used to search the compounds of Sini Decoction plus Ginseng with oral bioavailability（OB）≥30% and druglikeness（ DL）≥0.18，and the results were input into the UniProt database and converted into standard target names；Genecards and OMIM database were used to find COVID-19 target, and the intersection targets were obtained and Venn diagram was drawn. Cytoscape 3.7.2 was applied to make the network diagram of composition-disease-target；The interaction database platform-String was used to analyze the target protein interaction, and the data were input into the software of Cytoscape 3.7.2 to make the network diagram；David database was used to analyze the accumulation of Gene Ontology（GO）and Kyoto Encyclopedia of Genes and Genomes（KEGG）signaling pathways of drug-disease intersection targets. The component target pathway network was constructed by using Cytoscape 3.7.2. Results: Altogether, 112 active components of Sini Decoction plus Ginseng were screened, corresponding to 234 targets. Besides, 261 COVID-19 targets were obtained after screening, and the Venn map showed that 50 targets were intersected. Quercetin, kaempferol，naringenin，and β-sitosterol were found to have higher moderate values shown by the component-disease-target network. The target proteins with high PPI network analysis value were IL-6，MAPK8，MAPK3， MAPK1，TP53，TNF，and CASP3. GO enrichment function analysis showed that 341 biological processes, 33 cell components，and 50 molecular functions were involved，which showed inflammatory reaction，cell response to lipopolysaccharide，exogenous apoptosis signal pathway，positive regulation of RNA polymerase Ⅱ promoter transcription，cytokine activity，chemokine activity，heme binding，and other biological processes. KEGG signaling pathway enrichment function analysisshowed that there were 112 signaling pathways. It included TNF signaling pathway，tuberculosis，influenza A，PI3K Akt signaling pathway，HIF-1 signaling pathway，and Toll-like receptor signaling pathway. According to the component-target-pathway network diagram，quercetin，kaempferol，naringenin， and β -sitosterol in Sini Decoction plus Ginseng may act on IL-6，MAPK8， MAPK3， MAPK1，TP53，TNF，CASP3，and other targets through TNF signaling pathway，MAPK signaling pathway，Tolllike receptor signaling pathway，PI3K-Akt signaling pathway，and HIF-1 signaling pathway. Conclusion：Sini Decoction plus Ginseng can affect COVID-19 through multiple active components，multiple targets，and multiple pathways.
format	article
author	Xin-Hua Zhao Song-Jiang Liu
author_facet	Xin-Hua Zhao Song-Jiang Liu
author_sort	Xin-Hua Zhao
title	Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
title_short	Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
title_full	Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
title_fullStr	Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
title_full_unstemmed	Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an
title_sort	effect of sini decoction plus ginseng on covid-19 based on network pharmacological an
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/b42e6f20a51c414c82f98e868de72d37
work_keys_str_mv	AT xinhuazhao effectofsinidecoctionplusginsengoncovid19basedonnetworkpharmacologicalan AT songjiangliu effectofsinidecoctionplusginsengoncovid19basedonnetworkpharmacologicalan
_version_	1718426806955016192

Effect of Sini Decoction plus Ginseng on COVID-19 based on network pharmacological an

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