Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer

The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-microorganism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such a...

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Autores principales:	Giusi Alberti, Margherita Mazzola, Carola Gagliardo, Alessandro Pitruzzella, Alberto Fucarini, Marco Giammanco, Giovanni Tomasello, Francesco Carini
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	extracellular vesicles gut microbiota inflammatory bowel disease colorectal cancer Medicine R
Acceso en línea:	https://doaj.org/article/b42fe022ab424d2aa1790dcd6bf4c91c
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spelling	oai:doaj.org-article:b42fe022ab424d2aa1790dcd6bf4c91c2021-11-29T08:47:12ZExtracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer1213-81181804-752110.5507/bp.2021.042https://doaj.org/article/b42fe022ab424d2aa1790dcd6bf4c91c2021-09-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202103-0001_extracellular-vesicles-derived-from-gut-microbiota-in-inflammatory-bowel-disease-and-colorectal-cancer.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-microorganism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions.Giusi AlbertiMargherita MazzolaCarola GagliardoAlessandro PitruzzellaAlberto FucariniMarco GiammancoGiovanni TomaselloFrancesco CariniPalacký University Olomouc, Faculty of Medicine and Dentistryarticleextracellular vesiclesgut microbiotainflammatory bowel diseasecolorectal cancerMedicineRENBiomedical Papers, Vol 165, Iss 3, Pp 233-240 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles gut microbiota inflammatory bowel disease colorectal cancer Medicine R
spellingShingle	extracellular vesicles gut microbiota inflammatory bowel disease colorectal cancer Medicine R Giusi Alberti Margherita Mazzola Carola Gagliardo Alessandro Pitruzzella Alberto Fucarini Marco Giammanco Giovanni Tomasello Francesco Carini Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
description	The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-microorganism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions.
format	article
author	Giusi Alberti Margherita Mazzola Carola Gagliardo Alessandro Pitruzzella Alberto Fucarini Marco Giammanco Giovanni Tomasello Francesco Carini
author_facet	Giusi Alberti Margherita Mazzola Carola Gagliardo Alessandro Pitruzzella Alberto Fucarini Marco Giammanco Giovanni Tomasello Francesco Carini
author_sort	Giusi Alberti
title	Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
title_short	Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
title_full	Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
title_fullStr	Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
title_full_unstemmed	Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
title_sort	extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/b42fe022ab424d2aa1790dcd6bf4c91c
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Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer

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