Investigating the effect of trigger delay on cardiac 31P MRS signals

Abstract The heart’s geometry and its metabolic activity vary over the cardiac cycle. The effect of these fluctuations on phosphorus (31P) magnetic resonance spectroscopy (MRS) data quality and metabolite ratios was investigated. 12 healthy volunteers were measured using a 7 T MR scanner and a cardi...

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Autores principales:	Stefan Wampl, Tito Körner, Ladislav Valkovič, Siegfried Trattnig, Michael Wolzt, Martin Meyerspeer, Albrecht Ingo Schmid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b42fe4a36f9c4effa064b5da8748a15a
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spelling	oai:doaj.org-article:b42fe4a36f9c4effa064b5da8748a15a2021-12-02T13:41:10ZInvestigating the effect of trigger delay on cardiac 31P MRS signals10.1038/s41598-021-87063-82045-2322https://doaj.org/article/b42fe4a36f9c4effa064b5da8748a15a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87063-8https://doaj.org/toc/2045-2322Abstract The heart’s geometry and its metabolic activity vary over the cardiac cycle. The effect of these fluctuations on phosphorus (31P) magnetic resonance spectroscopy (MRS) data quality and metabolite ratios was investigated. 12 healthy volunteers were measured using a 7 T MR scanner and a cardiac 31P-1H loop coil. 31P chemical shift imaging data were acquired untriggered and at four different times during the cardiac cycle using acoustic triggering. Signals of adenosine-triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and 2,3-diphosphoglycerate (2,3-DPG) and their fit quality as Cramér-Rao lower bounds (CRLB) were quantified including corrections for contamination by 31P signals from blood, flip angle, saturation and total acquisition time. The myocardial filling factor was estimated from cine short axis views. The corrected signals of PCr and $$\gamma$$ γ -ATP were higher during end-systole and lower during diastasis than in untriggered acquisitions ( $$P<0.05$$ P < 0.05 ). Signal intensities of untriggered scans were between those with triggering to end-systole and diastasis. Fit quality of PCr and $$\gamma$$ γ -ATP peaks was best during end-systole when blood contamination of ATP and Pi signals was lowest. While metabolite ratios and pH remained stable over the cardiac cycle, signal amplitudes correlated strongly with myocardial voxel filling. Triggering of cardiac 31P MRS acquisitions improves signal amplitudes and fit quality if the trigger delay is set to end-systole. We conclude that triggering to end-systole is superior to triggering to diastasis.Stefan WamplTito KörnerLadislav ValkovičSiegfried TrattnigMichael WolztMartin MeyerspeerAlbrecht Ingo SchmidNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan Wampl Tito Körner Ladislav Valkovič Siegfried Trattnig Michael Wolzt Martin Meyerspeer Albrecht Ingo Schmid Investigating the effect of trigger delay on cardiac 31P MRS signals
description	Abstract The heart’s geometry and its metabolic activity vary over the cardiac cycle. The effect of these fluctuations on phosphorus (31P) magnetic resonance spectroscopy (MRS) data quality and metabolite ratios was investigated. 12 healthy volunteers were measured using a 7 T MR scanner and a cardiac 31P-1H loop coil. 31P chemical shift imaging data were acquired untriggered and at four different times during the cardiac cycle using acoustic triggering. Signals of adenosine-triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and 2,3-diphosphoglycerate (2,3-DPG) and their fit quality as Cramér-Rao lower bounds (CRLB) were quantified including corrections for contamination by 31P signals from blood, flip angle, saturation and total acquisition time. The myocardial filling factor was estimated from cine short axis views. The corrected signals of PCr and $$\gamma$$ γ -ATP were higher during end-systole and lower during diastasis than in untriggered acquisitions ( $$P<0.05$$ P < 0.05 ). Signal intensities of untriggered scans were between those with triggering to end-systole and diastasis. Fit quality of PCr and $$\gamma$$ γ -ATP peaks was best during end-systole when blood contamination of ATP and Pi signals was lowest. While metabolite ratios and pH remained stable over the cardiac cycle, signal amplitudes correlated strongly with myocardial voxel filling. Triggering of cardiac 31P MRS acquisitions improves signal amplitudes and fit quality if the trigger delay is set to end-systole. We conclude that triggering to end-systole is superior to triggering to diastasis.
format	article
author	Stefan Wampl Tito Körner Ladislav Valkovič Siegfried Trattnig Michael Wolzt Martin Meyerspeer Albrecht Ingo Schmid
author_facet	Stefan Wampl Tito Körner Ladislav Valkovič Siegfried Trattnig Michael Wolzt Martin Meyerspeer Albrecht Ingo Schmid
author_sort	Stefan Wampl
title	Investigating the effect of trigger delay on cardiac 31P MRS signals
title_short	Investigating the effect of trigger delay on cardiac 31P MRS signals
title_full	Investigating the effect of trigger delay on cardiac 31P MRS signals
title_fullStr	Investigating the effect of trigger delay on cardiac 31P MRS signals
title_full_unstemmed	Investigating the effect of trigger delay on cardiac 31P MRS signals
title_sort	investigating the effect of trigger delay on cardiac 31p mrs signals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b42fe4a36f9c4effa064b5da8748a15a
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Investigating the effect of trigger delay on cardiac 31P MRS signals

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