Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model

Abstract We estimated national-level trends in the prevalence of probable active syphilis in adult women using the Spectrum Sexually Transmitted Infections (STI) model to inform program planning, target-setting, and progress evaluation in STI control. The model fitted smoothed-splines polynomial reg...

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Autores principales:	Eline L. Korenromp, S. Guy Mahiané, Nico Nagelkerke, Melanie M. Taylor, Rebecca Williams, R. Matthew Chico, Carel Pretorius, Laith J. Abu-Raddad, Jane Rowley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b431cac18dfa45c2bbc6f0644c23ed17
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spelling	oai:doaj.org-article:b431cac18dfa45c2bbc6f0644c23ed172021-12-02T11:41:25ZSyphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model10.1038/s41598-018-29805-92045-2322https://doaj.org/article/b431cac18dfa45c2bbc6f0644c23ed172018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29805-9https://doaj.org/toc/2045-2322Abstract We estimated national-level trends in the prevalence of probable active syphilis in adult women using the Spectrum Sexually Transmitted Infections (STI) model to inform program planning, target-setting, and progress evaluation in STI control. The model fitted smoothed-splines polynomial regressions to data from antenatal clinic surveys and screening and representative household surveys, adjusted for diagnostic test performance and weighted by national coverage. Eligible countries had ≥1 data point from 2010 or later and ≥3 from 2000 or later from adult populations considered representative of the general female population (pregnant women or community-based studies). Between 2012 and 2016, the prevalence of probable active syphilis in women decreased in 54 (41%) of 132 eligible countries; this decrease was substantive (≥10% proportionally, ≥0.10% percentage-point absolute difference and non-overlapping 95% confidence intervals in 2012 and 2016) in 5 countries. Restricting eligible data to prevalence measurements of dual treponemal and non-treponemal testing limited estimates to 85 countries; of these, 45 countries (53%) showed a decrease. These standardized trend estimates highlight the need for increased investment in national syphilis surveillance and control efforts if the World Health Organization target of a 90% reduction in the incidence of syphilis between 2018 and 2030 is to be met.Eline L. KorenrompS. Guy MahianéNico NagelkerkeMelanie M. TaylorRebecca WilliamsR. Matthew ChicoCarel PretoriusLaith J. Abu-RaddadJane RowleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eline L. Korenromp S. Guy Mahiané Nico Nagelkerke Melanie M. Taylor Rebecca Williams R. Matthew Chico Carel Pretorius Laith J. Abu-Raddad Jane Rowley Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
description	Abstract We estimated national-level trends in the prevalence of probable active syphilis in adult women using the Spectrum Sexually Transmitted Infections (STI) model to inform program planning, target-setting, and progress evaluation in STI control. The model fitted smoothed-splines polynomial regressions to data from antenatal clinic surveys and screening and representative household surveys, adjusted for diagnostic test performance and weighted by national coverage. Eligible countries had ≥1 data point from 2010 or later and ≥3 from 2000 or later from adult populations considered representative of the general female population (pregnant women or community-based studies). Between 2012 and 2016, the prevalence of probable active syphilis in women decreased in 54 (41%) of 132 eligible countries; this decrease was substantive (≥10% proportionally, ≥0.10% percentage-point absolute difference and non-overlapping 95% confidence intervals in 2012 and 2016) in 5 countries. Restricting eligible data to prevalence measurements of dual treponemal and non-treponemal testing limited estimates to 85 countries; of these, 45 countries (53%) showed a decrease. These standardized trend estimates highlight the need for increased investment in national syphilis surveillance and control efforts if the World Health Organization target of a 90% reduction in the incidence of syphilis between 2018 and 2030 is to be met.
format	article
author	Eline L. Korenromp S. Guy Mahiané Nico Nagelkerke Melanie M. Taylor Rebecca Williams R. Matthew Chico Carel Pretorius Laith J. Abu-Raddad Jane Rowley
author_facet	Eline L. Korenromp S. Guy Mahiané Nico Nagelkerke Melanie M. Taylor Rebecca Williams R. Matthew Chico Carel Pretorius Laith J. Abu-Raddad Jane Rowley
author_sort	Eline L. Korenromp
title	Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
title_short	Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
title_full	Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
title_fullStr	Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
title_full_unstemmed	Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model
title_sort	syphilis prevalence trends in adult women in 132 countries – estimations using the spectrum sexually transmitted infections model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b431cac18dfa45c2bbc6f0644c23ed17
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Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model

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