High-throughput rapid-prototyping of low-cost paper-based microfluidics

Abstract Paper-based micro analytical devices offer significant advantages compared to the conventional microfluidic chips including cost-effectiveness, ease of fabrication, and ease of use while preserving critical features including strong capillary action and biological compatibility. In this wor...

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Autores principales:	Fariba Ghaderinezhad, Reza Amin, Mikail Temirel, Bekir Yenilmez, Adam Wentworth, Savas Tasoglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b43245243ad444f89b55c8552cf68420
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spelling	oai:doaj.org-article:b43245243ad444f89b55c8552cf684202021-12-02T11:52:18ZHigh-throughput rapid-prototyping of low-cost paper-based microfluidics10.1038/s41598-017-02931-62045-2322https://doaj.org/article/b43245243ad444f89b55c8552cf684202017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02931-6https://doaj.org/toc/2045-2322Abstract Paper-based micro analytical devices offer significant advantages compared to the conventional microfluidic chips including cost-effectiveness, ease of fabrication, and ease of use while preserving critical features including strong capillary action and biological compatibility. In this work, we demonstrate an inexpensive, rapid method for high-throughput fabrication of paper-based microfluidics by patterning hydrophobic barriers using a desktop pen plotter integrated with a custom-made, low-cost paper feeder. We tested various types of commercial permanent markers and compared their water-resistant capabilities for creating hydrophobic barriers. Additionally, we studied the performance of markers with different types of paper, plotting speeds, and pattern dimensions. To verify the effectiveness of the presented fabrication method, colorimetric analysis was performed on the results of a glucose assay.Fariba GhaderinezhadReza AminMikail TemirelBekir YenilmezAdam WentworthSavas TasogluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fariba Ghaderinezhad Reza Amin Mikail Temirel Bekir Yenilmez Adam Wentworth Savas Tasoglu High-throughput rapid-prototyping of low-cost paper-based microfluidics
description	Abstract Paper-based micro analytical devices offer significant advantages compared to the conventional microfluidic chips including cost-effectiveness, ease of fabrication, and ease of use while preserving critical features including strong capillary action and biological compatibility. In this work, we demonstrate an inexpensive, rapid method for high-throughput fabrication of paper-based microfluidics by patterning hydrophobic barriers using a desktop pen plotter integrated with a custom-made, low-cost paper feeder. We tested various types of commercial permanent markers and compared their water-resistant capabilities for creating hydrophobic barriers. Additionally, we studied the performance of markers with different types of paper, plotting speeds, and pattern dimensions. To verify the effectiveness of the presented fabrication method, colorimetric analysis was performed on the results of a glucose assay.
format	article
author	Fariba Ghaderinezhad Reza Amin Mikail Temirel Bekir Yenilmez Adam Wentworth Savas Tasoglu
author_facet	Fariba Ghaderinezhad Reza Amin Mikail Temirel Bekir Yenilmez Adam Wentworth Savas Tasoglu
author_sort	Fariba Ghaderinezhad
title	High-throughput rapid-prototyping of low-cost paper-based microfluidics
title_short	High-throughput rapid-prototyping of low-cost paper-based microfluidics
title_full	High-throughput rapid-prototyping of low-cost paper-based microfluidics
title_fullStr	High-throughput rapid-prototyping of low-cost paper-based microfluidics
title_full_unstemmed	High-throughput rapid-prototyping of low-cost paper-based microfluidics
title_sort	high-throughput rapid-prototyping of low-cost paper-based microfluidics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b43245243ad444f89b55c8552cf68420
work_keys_str_mv	AT faribaghaderinezhad highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics AT rezaamin highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics AT mikailtemirel highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics AT bekiryenilmez highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics AT adamwentworth highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics AT savastasoglu highthroughputrapidprototypingoflowcostpaperbasedmicrofluidics
_version_	1718395127418847232

High-throughput rapid-prototyping of low-cost paper-based microfluidics

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