The Gαi-GIV binding interface is a druggable protein-protein interaction

Abstract Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also GEFs. GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascribed to a well-defined protein seque...

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Autores principales: Vincent DiGiacomo, Alain Ibáñez de Opakua, Maria P. Papakonstantinou, Lien T. Nguyen, Nekane Merino, Juan B. Blanco-Canosa, Francisco J. Blanco, Mikel Garcia-Marcos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b433a7a3090546b08a7b912bf7b9d6f6
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