Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease

Aim. To evaluate the association between coronary collateral circulation (CCC) and carbohydrate metabolism disorders (CMD) in patients with chronic coronary artery disease (CAD). Materials and Methods. Six hundred three patients with chronic CAD were included in this cohort cross-sectional study....

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Autores principales:	Ivan Vasil'evich Starostin, Konstantin Alexandrovich Talitskiy, Olga Samuilovna Bulkina, Anatoly Nikolaevich Samko, Yury Alexandrovich Karpov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	collateral circulation, carbohydrate metabolism, coronary artery disease Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/b434de63f3cb4f65b1505f1286cef6ee
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spelling	oai:doaj.org-article:b434de63f3cb4f65b1505f1286cef6ee2021-11-14T09:00:19ZCarbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease2072-03512072-037810.14341/DM2015261-68https://doaj.org/article/b434de63f3cb4f65b1505f1286cef6ee2015-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7084https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate the association between coronary collateral circulation (CCC) and carbohydrate metabolism disorders (CMD) in patients with chronic coronary artery disease (CAD). Materials and Methods. Six hundred three patients with chronic CAD were included in this cohort cross-sectional study. Coronary angiography images were used to quantify coronary circulation, including CCC evaluation, with a modified technique proposed by Rentrop. CMD were classified according to the WHO criteria.Potential associations between CMD and CCC were evaluated using multiple linear models that incorporated major angiographic, clinical and laboratory parameters. Results. Among the 603 patients with chronic CAD, 47.4 had CMD, including type 2 diabetes mellitus in 24.2% of the patients, impaired glucose tolerance in 2.8%, type 1 diabetes mellitus in 1.0% and unspecified CMD in 16.1%. CMD were independently associated with lower CCC [odds ratio (OR). = 0.96, p . = 0.003). CMD were independently associated with a decrease in the association . between maximum diameter stenosis and CCC (OR = 0.93, p. = 0.005). No independent associations were found between CCC and type of anti-diabetic treatment, HbA1c levels, insulin resistance (HOMA index), or metabolic syndrome components (body mass index, triglycerides, fasting glucose levels, LDLP cholesterol and arterial hypertension). Conclusion. CMD in patients with chronic CAD are . independently associated with worse CCC. The presence of CMD weakens . the association between maximum diameter stenosis and CCC. Metabolic syndrome components, blood glucose control and anti-diabetic treatment modality were not found to influence CCC.Ivan Vasil'evich StarostinKonstantin Alexandrovich TalitskiyOlga Samuilovna BulkinaAnatoly Nikolaevich SamkoYury Alexandrovich KarpovEndocrinology Research Centrearticlecollateral circulation, carbohydrate metabolism, coronary artery diseaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 2, Pp 61-68 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	collateral circulation, carbohydrate metabolism, coronary artery disease Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	collateral circulation, carbohydrate metabolism, coronary artery disease Nutritional diseases. Deficiency diseases RC620-627 Ivan Vasil'evich Starostin Konstantin Alexandrovich Talitskiy Olga Samuilovna Bulkina Anatoly Nikolaevich Samko Yury Alexandrovich Karpov Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
description	Aim. To evaluate the association between coronary collateral circulation (CCC) and carbohydrate metabolism disorders (CMD) in patients with chronic coronary artery disease (CAD). Materials and Methods. Six hundred three patients with chronic CAD were included in this cohort cross-sectional study. Coronary angiography images were used to quantify coronary circulation, including CCC evaluation, with a modified technique proposed by Rentrop. CMD were classified according to the WHO criteria.Potential associations between CMD and CCC were evaluated using multiple linear models that incorporated major angiographic, clinical and laboratory parameters. Results. Among the 603 patients with chronic CAD, 47.4 had CMD, including type 2 diabetes mellitus in 24.2% of the patients, impaired glucose tolerance in 2.8%, type 1 diabetes mellitus in 1.0% and unspecified CMD in 16.1%. CMD were independently associated with lower CCC [odds ratio (OR). = 0.96, p . = 0.003). CMD were independently associated with a decrease in the association . between maximum diameter stenosis and CCC (OR = 0.93, p. = 0.005). No independent associations were found between CCC and type of anti-diabetic treatment, HbA1c levels, insulin resistance (HOMA index), or metabolic syndrome components (body mass index, triglycerides, fasting glucose levels, LDLP cholesterol and arterial hypertension). Conclusion. CMD in patients with chronic CAD are . independently associated with worse CCC. The presence of CMD weakens . the association between maximum diameter stenosis and CCC. Metabolic syndrome components, blood glucose control and anti-diabetic treatment modality were not found to influence CCC.
format	article
author	Ivan Vasil'evich Starostin Konstantin Alexandrovich Talitskiy Olga Samuilovna Bulkina Anatoly Nikolaevich Samko Yury Alexandrovich Karpov
author_facet	Ivan Vasil'evich Starostin Konstantin Alexandrovich Talitskiy Olga Samuilovna Bulkina Anatoly Nikolaevich Samko Yury Alexandrovich Karpov
author_sort	Ivan Vasil'evich Starostin
title	Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
title_short	Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
title_full	Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
title_fullStr	Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
title_full_unstemmed	Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
title_sort	carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/b434de63f3cb4f65b1505f1286cef6ee
work_keys_str_mv	AT ivanvasilevichstarostin carbohydratemetabolismdisordersandcoronarycollateralcirculationinpatientswithchroniccoronaryarterydisease AT konstantinalexandrovichtalitskiy carbohydratemetabolismdisordersandcoronarycollateralcirculationinpatientswithchroniccoronaryarterydisease AT olgasamuilovnabulkina carbohydratemetabolismdisordersandcoronarycollateralcirculationinpatientswithchroniccoronaryarterydisease AT anatolynikolaevichsamko carbohydratemetabolismdisordersandcoronarycollateralcirculationinpatientswithchroniccoronaryarterydisease AT yuryalexandrovichkarpov carbohydratemetabolismdisordersandcoronarycollateralcirculationinpatientswithchroniccoronaryarterydisease
_version_	1718429551537684480

Carbohydrate metabolism disorders and coronary collateral circulation in patients with chronic coronary artery disease

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