Genomic programming of IRF4-expressing human Langerhans cells

Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimul...

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Autores principales:	Sofia Sirvent, Andres F. Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeongmin Woo, Jeremy Riddell, Virendra K. Chaudhri, Patrick Stumpf, Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H. Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S. Friedmann, Matthew T. Weirauch, Harinder Singh, Marta E. Polak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b437083920e842f086e6d17c31b3b048
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spelling	oai:doaj.org-article:b437083920e842f086e6d17c31b3b0482021-12-02T13:23:48ZGenomic programming of IRF4-expressing human Langerhans cells10.1038/s41467-019-14125-x2041-1723https://doaj.org/article/b437083920e842f086e6d17c31b3b0482020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14125-xhttps://doaj.org/toc/2041-1723Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.Sofia SirventAndres F. VallejoJames DaviesKalum ClaytonZhiguo WuJeongmin WooJeremy RiddellVirendra K. ChaudhriPatrick StumpfLiliya Angelova NazlamovaGabrielle WhewayMatthew Rose-ZerilliJonathan WestMario PujatoXiaoting ChenChristopher H. WoelkBen MacArthurMichael Ardern-JonesPeter S. FriedmannMatthew T. WeirauchHarinder SinghMarta E. PolakNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sofia Sirvent Andres F. Vallejo James Davies Kalum Clayton Zhiguo Wu Jeongmin Woo Jeremy Riddell Virendra K. Chaudhri Patrick Stumpf Liliya Angelova Nazlamova Gabrielle Wheway Matthew Rose-Zerilli Jonathan West Mario Pujato Xiaoting Chen Christopher H. Woelk Ben MacArthur Michael Ardern-Jones Peter S. Friedmann Matthew T. Weirauch Harinder Singh Marta E. Polak Genomic programming of IRF4-expressing human Langerhans cells
description	Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.
format	article
author	Sofia Sirvent Andres F. Vallejo James Davies Kalum Clayton Zhiguo Wu Jeongmin Woo Jeremy Riddell Virendra K. Chaudhri Patrick Stumpf Liliya Angelova Nazlamova Gabrielle Wheway Matthew Rose-Zerilli Jonathan West Mario Pujato Xiaoting Chen Christopher H. Woelk Ben MacArthur Michael Ardern-Jones Peter S. Friedmann Matthew T. Weirauch Harinder Singh Marta E. Polak
author_facet	Sofia Sirvent Andres F. Vallejo James Davies Kalum Clayton Zhiguo Wu Jeongmin Woo Jeremy Riddell Virendra K. Chaudhri Patrick Stumpf Liliya Angelova Nazlamova Gabrielle Wheway Matthew Rose-Zerilli Jonathan West Mario Pujato Xiaoting Chen Christopher H. Woelk Ben MacArthur Michael Ardern-Jones Peter S. Friedmann Matthew T. Weirauch Harinder Singh Marta E. Polak
author_sort	Sofia Sirvent
title	Genomic programming of IRF4-expressing human Langerhans cells
title_short	Genomic programming of IRF4-expressing human Langerhans cells
title_full	Genomic programming of IRF4-expressing human Langerhans cells
title_fullStr	Genomic programming of IRF4-expressing human Langerhans cells
title_full_unstemmed	Genomic programming of IRF4-expressing human Langerhans cells
title_sort	genomic programming of irf4-expressing human langerhans cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b437083920e842f086e6d17c31b3b048
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Genomic programming of IRF4-expressing human Langerhans cells

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