Association between Parkinson’s disease and the faecal eukaryotic microbiota

Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative disease, and is so far not considered curable. PD patients suffer from several motor and non-motor symptoms, including gastrointestinal dysfunctions and alterations of the enteric nervous system. Constipation and additiona...

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Autores principales:	Severin Weis, Alexandra Meisner, Andreas Schwiertz, Marcus M. Unger, Anouck Becker, Klaus Faßbender, Sylvia Schnell, Karl-Herbert Schäfer, Markus Egert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b43a5de64b4c404a96985bf3fa5b0f2a
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spelling	oai:doaj.org-article:b43a5de64b4c404a96985bf3fa5b0f2a2021-11-21T12:26:42ZAssociation between Parkinson’s disease and the faecal eukaryotic microbiota10.1038/s41531-021-00244-02373-8057https://doaj.org/article/b43a5de64b4c404a96985bf3fa5b0f2a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00244-0https://doaj.org/toc/2373-8057Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative disease, and is so far not considered curable. PD patients suffer from several motor and non-motor symptoms, including gastrointestinal dysfunctions and alterations of the enteric nervous system. Constipation and additional intestinal affections can precede the classical motor symptoms by several years. Recently, we reported effects of PD and related medications on the faecal bacterial community of 34 German PD patients and 25 age-matched controls. Here, we used the same collective and analysed the V6 and V7 hypervariable region of PCR-amplified, eukaryotic 18S rRNA genes using an Illumina MiSeq platform. In all, 53% (18) of the PD samples and 72% (18) of the control samples yielded sufficient amplicons for downstream community analyses. The PD samples showed a significantly lower alpha and a different beta eukaryotic diversity than the controls. Most strikingly, we observed a significantly higher relative abundance of sequence affiliated with the Geotrichum genus in the PD samples (39.7%), when compared to the control samples (0.05%). In addition, we observed lower relative abundances of sequences affiliated with Aspergillus/Penicillium, Charophyta/Linum, unidentified Opisthokonta and three genera of minor abundant zooflagellates in the PD samples. Our data add knowledge to the small body of data about the eukaryotic microbiota of PD patients and suggest a potential association of certain gut eukaryotes and PD.Severin WeisAlexandra MeisnerAndreas SchwiertzMarcus M. UngerAnouck BeckerKlaus FaßbenderSylvia SchnellKarl-Herbert SchäferMarkus EgertNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Severin Weis Alexandra Meisner Andreas Schwiertz Marcus M. Unger Anouck Becker Klaus Faßbender Sylvia Schnell Karl-Herbert Schäfer Markus Egert Association between Parkinson’s disease and the faecal eukaryotic microbiota
description	Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative disease, and is so far not considered curable. PD patients suffer from several motor and non-motor symptoms, including gastrointestinal dysfunctions and alterations of the enteric nervous system. Constipation and additional intestinal affections can precede the classical motor symptoms by several years. Recently, we reported effects of PD and related medications on the faecal bacterial community of 34 German PD patients and 25 age-matched controls. Here, we used the same collective and analysed the V6 and V7 hypervariable region of PCR-amplified, eukaryotic 18S rRNA genes using an Illumina MiSeq platform. In all, 53% (18) of the PD samples and 72% (18) of the control samples yielded sufficient amplicons for downstream community analyses. The PD samples showed a significantly lower alpha and a different beta eukaryotic diversity than the controls. Most strikingly, we observed a significantly higher relative abundance of sequence affiliated with the Geotrichum genus in the PD samples (39.7%), when compared to the control samples (0.05%). In addition, we observed lower relative abundances of sequences affiliated with Aspergillus/Penicillium, Charophyta/Linum, unidentified Opisthokonta and three genera of minor abundant zooflagellates in the PD samples. Our data add knowledge to the small body of data about the eukaryotic microbiota of PD patients and suggest a potential association of certain gut eukaryotes and PD.
format	article
author	Severin Weis Alexandra Meisner Andreas Schwiertz Marcus M. Unger Anouck Becker Klaus Faßbender Sylvia Schnell Karl-Herbert Schäfer Markus Egert
author_facet	Severin Weis Alexandra Meisner Andreas Schwiertz Marcus M. Unger Anouck Becker Klaus Faßbender Sylvia Schnell Karl-Herbert Schäfer Markus Egert
author_sort	Severin Weis
title	Association between Parkinson’s disease and the faecal eukaryotic microbiota
title_short	Association between Parkinson’s disease and the faecal eukaryotic microbiota
title_full	Association between Parkinson’s disease and the faecal eukaryotic microbiota
title_fullStr	Association between Parkinson’s disease and the faecal eukaryotic microbiota
title_full_unstemmed	Association between Parkinson’s disease and the faecal eukaryotic microbiota
title_sort	association between parkinson’s disease and the faecal eukaryotic microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b43a5de64b4c404a96985bf3fa5b0f2a
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Association between Parkinson’s disease and the faecal eukaryotic microbiota

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