COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY

Objective: To compare the hemodynamic effects of Atracurium versus Cisatracurium in Cardiac Patients Undergoing coronary artery bypass graft Surgery. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted at Armed Forces Institute of Rawalpindi, a terti...

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Autores principales:	Muhammad Ali, Syed Aqeel Hussain, Rashad Siddiqi, Fahad Ahmad Khan, Rehana Javaid, Rahmeen Pervaiz Khan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	atracurium cisatracurium diastolic blood pressure hemodynamic effects heart rate mean arterial pressure systolic blood pressure Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b43c06b75ba14e44a7ecf015d99d209a
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spelling	oai:doaj.org-article:b43c06b75ba14e44a7ecf015d99d209a2021-12-02T19:18:13ZCOMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERYdoi.org/10.51253/pafmj.v70iSuppl-4.60410030-96482411-8842https://doaj.org/article/b43c06b75ba14e44a7ecf015d99d209a2020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6041https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the hemodynamic effects of Atracurium versus Cisatracurium in Cardiac Patients Undergoing coronary artery bypass graft Surgery. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted at Armed Forces Institute of Rawalpindi, a tertiary care hospital, after seeking hospital ethics committee permission, from Apr 2019 to Oct 2019. Methodology: A total of 200 consecutive patients were randomized into two equal groups, group-A and group-C (100 in each group). Group-A patients were induced with 0.5mg/kg of Atracurium, followed by infusion @ 10μg/kg/min whereas group C patients received Cisatracurium @ 0.2mg/kg at induction, followed by infusion @ 2μg/kg/min during the maintainence phase. Systolic blood pressure, diastolic blood pressure, Mean arterial pressure and heart rate were noted at different intervals of both groups. Decrease in systolic blood pressure of >20% from baseline or a value <90 mmHg was considered as hypotension. Results: The mean age of patients was 57.5 ± 6.75 years and 56.52 ± 4.46 years in group A and group C respectively. Systolic and diastolic blood pressure was better maintained with cisatracurium than atracurium. Also Mean arterial pressure remained more stable with cisatracurium (p<0.05), but after opening of sternum and before going on cardiopulmonary bypass, the difference was insignificant in both groups (p>0.05). Heart rate remained more steady with cisatracurium (p<0.05) but had insignificant difference before going on cardiopulmonary bypass (p>0.05). Conclusion: Cisatracurium found to be more suitable drug in maintaining the stable hemodynamics and preventing fluctuations in pressure in cardiac patients undergoing on-pump bypass surgery.Muhammad AliSyed Aqeel HussainRashad SiddiqiFahad Ahmad KhanRehana JavaidRahmeen Pervaiz KhanArmy Medical College Rawalpindiarticleatracuriumcisatracuriumdiastolic blood pressurehemodynamic effectsheart ratemean arterial pressuresystolic blood pressureMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 4, Pp 843-848 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	atracurium cisatracurium diastolic blood pressure hemodynamic effects heart rate mean arterial pressure systolic blood pressure Medicine R Medicine (General) R5-920
spellingShingle	atracurium cisatracurium diastolic blood pressure hemodynamic effects heart rate mean arterial pressure systolic blood pressure Medicine R Medicine (General) R5-920 Muhammad Ali Syed Aqeel Hussain Rashad Siddiqi Fahad Ahmad Khan Rehana Javaid Rahmeen Pervaiz Khan COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
description	Objective: To compare the hemodynamic effects of Atracurium versus Cisatracurium in Cardiac Patients Undergoing coronary artery bypass graft Surgery. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted at Armed Forces Institute of Rawalpindi, a tertiary care hospital, after seeking hospital ethics committee permission, from Apr 2019 to Oct 2019. Methodology: A total of 200 consecutive patients were randomized into two equal groups, group-A and group-C (100 in each group). Group-A patients were induced with 0.5mg/kg of Atracurium, followed by infusion @ 10μg/kg/min whereas group C patients received Cisatracurium @ 0.2mg/kg at induction, followed by infusion @ 2μg/kg/min during the maintainence phase. Systolic blood pressure, diastolic blood pressure, Mean arterial pressure and heart rate were noted at different intervals of both groups. Decrease in systolic blood pressure of >20% from baseline or a value <90 mmHg was considered as hypotension. Results: The mean age of patients was 57.5 ± 6.75 years and 56.52 ± 4.46 years in group A and group C respectively. Systolic and diastolic blood pressure was better maintained with cisatracurium than atracurium. Also Mean arterial pressure remained more stable with cisatracurium (p<0.05), but after opening of sternum and before going on cardiopulmonary bypass, the difference was insignificant in both groups (p>0.05). Heart rate remained more steady with cisatracurium (p<0.05) but had insignificant difference before going on cardiopulmonary bypass (p>0.05). Conclusion: Cisatracurium found to be more suitable drug in maintaining the stable hemodynamics and preventing fluctuations in pressure in cardiac patients undergoing on-pump bypass surgery.
format	article
author	Muhammad Ali Syed Aqeel Hussain Rashad Siddiqi Fahad Ahmad Khan Rehana Javaid Rahmeen Pervaiz Khan
author_facet	Muhammad Ali Syed Aqeel Hussain Rashad Siddiqi Fahad Ahmad Khan Rehana Javaid Rahmeen Pervaiz Khan
author_sort	Muhammad Ali
title	COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
title_short	COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
title_full	COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
title_fullStr	COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
title_full_unstemmed	COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY
title_sort	comparison between hemodynamic changes of atracurium and cisatracurium in patients undergoing cabg surgery
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/b43c06b75ba14e44a7ecf015d99d209a
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COMPARISON BETWEEN HEMODYNAMIC CHANGES OF ATRACURIUM AND CISATRACURIUM IN PATIENTS UNDERGOING CABG SURGERY

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