Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat

In Indonesia, hypertension is a condition that can lead to death through stroke and TB. Herbs have traditionally been used in Indonesia as an alternative medicine for lowering blood pressure. The leaves of Anredera cordifolia and Sonchus arvensis have been investigated for their antihypertensive pot...

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Autores principales:	Nova Suliska, Suryani, Muhamad Insanu, Elin Yulinah Sukandar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	anredera cordifolia antihypertension epinephrine sonchus arvensis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/b43f2ae715f84dc7850a781d2ea9ef41
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spelling	oai:doaj.org-article:b43f2ae715f84dc7850a781d2ea9ef412021-11-12T10:17:53ZAntihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat2231-40400976-209410.4103/japtr.japtr_91_21https://doaj.org/article/b43f2ae715f84dc7850a781d2ea9ef412021-01-01T00:00:00Zhttp://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=384;epage=388;aulast=Suliskahttps://doaj.org/toc/2231-4040https://doaj.org/toc/0976-2094In Indonesia, hypertension is a condition that can lead to death through stroke and TB. Herbs have traditionally been used in Indonesia as an alternative medicine for lowering blood pressure. The leaves of Anredera cordifolia and Sonchus arvensis have been investigated for their antihypertensive potential. Based on the number of treatments, rats were randomized into groups. Each group consists of five rats. The test animals were grouping as follows: the positive control group (hypertension induction without treatment), A. cordifolia 50 mg/kg b.w. group, A. cordifolia 100 mg/kg b.w., S. arvensis 50 mg/kg b.w, S. arvensis 100 mg/kg b.w., A. cordifolia 25 mg/kg b.w + S. arvensis 25 mg/kg b.w, A. cordifolia 50 mg/kg b.w + S. arvensis 50 mg/kg b.w, and atenolol 4.5 mg/kg b.w. The rats were given 0.25 mg/kg b.w. of epinephrine intraperitoneally. The initial, after induction, and final blood pressure of the animals were measured using the CODA® noninvasive blood pressure device. All animal test groups at T60 showed a significant difference in systolic and diastolic blood pressures to initial blood pressure (T0), P < 0.05. The combination of A. cordifolia 50 mg/kg b.w and S. arvensis 50 mg/kg b.w showed the highest percent inhibition of systolic and diastolic blood pressure. The combination of A. cordifolia and S. arvensis 50–50 mg/kg b.w showed the best effect of lowering systolic and diastolic blood pressure on the pathway of inhibiting adrenergic receptors.Nova SuliskaSuryaniMuhamad InsanuElin Yulinah SukandarWolters Kluwer Medknow Publicationsarticle anredera cordifolia antihypertensionepinephrine sonchus arvensis Therapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 4, Pp 384-388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anredera cordifolia antihypertension epinephrine sonchus arvensis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	anredera cordifolia antihypertension epinephrine sonchus arvensis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Nova Suliska Suryani Muhamad Insanu Elin Yulinah Sukandar Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
description	In Indonesia, hypertension is a condition that can lead to death through stroke and TB. Herbs have traditionally been used in Indonesia as an alternative medicine for lowering blood pressure. The leaves of Anredera cordifolia and Sonchus arvensis have been investigated for their antihypertensive potential. Based on the number of treatments, rats were randomized into groups. Each group consists of five rats. The test animals were grouping as follows: the positive control group (hypertension induction without treatment), A. cordifolia 50 mg/kg b.w. group, A. cordifolia 100 mg/kg b.w., S. arvensis 50 mg/kg b.w, S. arvensis 100 mg/kg b.w., A. cordifolia 25 mg/kg b.w + S. arvensis 25 mg/kg b.w, A. cordifolia 50 mg/kg b.w + S. arvensis 50 mg/kg b.w, and atenolol 4.5 mg/kg b.w. The rats were given 0.25 mg/kg b.w. of epinephrine intraperitoneally. The initial, after induction, and final blood pressure of the animals were measured using the CODA® noninvasive blood pressure device. All animal test groups at T60 showed a significant difference in systolic and diastolic blood pressures to initial blood pressure (T0), P < 0.05. The combination of A. cordifolia 50 mg/kg b.w and S. arvensis 50 mg/kg b.w showed the highest percent inhibition of systolic and diastolic blood pressure. The combination of A. cordifolia and S. arvensis 50–50 mg/kg b.w showed the best effect of lowering systolic and diastolic blood pressure on the pathway of inhibiting adrenergic receptors.
format	article
author	Nova Suliska Suryani Muhamad Insanu Elin Yulinah Sukandar
author_facet	Nova Suliska Suryani Muhamad Insanu Elin Yulinah Sukandar
author_sort	Nova Suliska
title	Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
title_short	Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
title_full	Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
title_fullStr	Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
title_full_unstemmed	Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat
title_sort	antihypertensive activity of combination of anredera cordifolia (ten.) v. steenis and sonchus arvensis l. leaves on epinephrine induced male wistar rat
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/b43f2ae715f84dc7850a781d2ea9ef41
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Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine Induced male Wistar Rat

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