The insulin-like growth factor system and its receptors: A potential novel anticancer target

Colin R. Lindsay1, T R Jeffry Evans1,21Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; 2University of Glasgow, CR-UK Beatson Laboratories, Garscube Estate, Glasgow, United KingdomAbstract: The current generation of novel anticancer therapies that are in preclinical and clinical deve...

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Autores principales:	Colin R. Lindsay, T R Jeffry Evans
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b44103bd7eed4cf18d00a23dd4b03d7b
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id	oai:doaj.org-article:b44103bd7eed4cf18d00a23dd4b03d7b
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spelling	oai:doaj.org-article:b44103bd7eed4cf18d00a23dd4b03d7b2021-12-02T05:11:46ZThe insulin-like growth factor system and its receptors: A potential novel anticancer target1177-54751177-5491https://doaj.org/article/b44103bd7eed4cf18d00a23dd4b03d7b2008-09-01T00:00:00Zhttp://www.dovepress.com/the-insulin-like-growth-factor-system-and-its-receptors-a-potential-no-a2238https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Colin R. Lindsay1, T R Jeffry Evans1,21Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; 2University of Glasgow, CR-UK Beatson Laboratories, Garscube Estate, Glasgow, United KingdomAbstract: The current generation of novel anticancer therapies that are in preclinical and clinical development are based on exploiting our increasing understanding of the molecular and cellular basis of cancer development and progression. Accelerated rates of cell division and proliferation have been postulated to predispose to the development of malignant disease. The insulin-like growth factor (IGF) signaling system has an important physiological role in regulating cellular proliferation and apoptosis. This function has led to considerable interest in its relevance to neoplasia over the last decade. In this review, we give an overview of the IGF system physiology, discuss the epidemiological significance of IGF signaling and neoplasia, and review the preclinical and clinical studies in targeting IGF receptors as cancer therapies.Keywords: insulin, growth factor, IGF-1, clinical trials Colin R. LindsayT R Jeffry EvansDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 855-864 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Colin R. Lindsay T R Jeffry Evans The insulin-like growth factor system and its receptors: A potential novel anticancer target
description	Colin R. Lindsay1, T R Jeffry Evans1,21Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; 2University of Glasgow, CR-UK Beatson Laboratories, Garscube Estate, Glasgow, United KingdomAbstract: The current generation of novel anticancer therapies that are in preclinical and clinical development are based on exploiting our increasing understanding of the molecular and cellular basis of cancer development and progression. Accelerated rates of cell division and proliferation have been postulated to predispose to the development of malignant disease. The insulin-like growth factor (IGF) signaling system has an important physiological role in regulating cellular proliferation and apoptosis. This function has led to considerable interest in its relevance to neoplasia over the last decade. In this review, we give an overview of the IGF system physiology, discuss the epidemiological significance of IGF signaling and neoplasia, and review the preclinical and clinical studies in targeting IGF receptors as cancer therapies.Keywords: insulin, growth factor, IGF-1, clinical trials
format	article
author	Colin R. Lindsay T R Jeffry Evans
author_facet	Colin R. Lindsay T R Jeffry Evans
author_sort	Colin R. Lindsay
title	The insulin-like growth factor system and its receptors: A potential novel anticancer target
title_short	The insulin-like growth factor system and its receptors: A potential novel anticancer target
title_full	The insulin-like growth factor system and its receptors: A potential novel anticancer target
title_fullStr	The insulin-like growth factor system and its receptors: A potential novel anticancer target
title_full_unstemmed	The insulin-like growth factor system and its receptors: A potential novel anticancer target
title_sort	insulin-like growth factor system and its receptors: a potential novel anticancer target
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b44103bd7eed4cf18d00a23dd4b03d7b
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The insulin-like growth factor system and its receptors: A potential novel anticancer target

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