Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems

Abstract Longitudinal analyses of magnetoencephalography (MEG) data are essential for a full understanding of the pathophysiology of brain diseases and the development of brain activity over time. However, time-dependent factors, such as the recording environment and the type of MEG recording system...

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Autores principales:	Lennard I. Boon, Prejaas Tewarie, Henk W. Berendse, Cornelis J. Stam, Arjan Hillebrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b443714be8d640a5bbe6d1d5c833c5a7
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spelling	oai:doaj.org-article:b443714be8d640a5bbe6d1d5c833c5a72021-12-02T18:50:49ZLongitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems10.1038/s41598-021-95363-22045-2322https://doaj.org/article/b443714be8d640a5bbe6d1d5c833c5a72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95363-2https://doaj.org/toc/2045-2322Abstract Longitudinal analyses of magnetoencephalography (MEG) data are essential for a full understanding of the pathophysiology of brain diseases and the development of brain activity over time. However, time-dependent factors, such as the recording environment and the type of MEG recording system may affect such longitudinal analyses. We hypothesized that, using source-space analysis, hardware and software differences between two recordings systems may be overcome, with the aim of finding consistent neurophysiological results. We studied eight healthy subjects who underwent three consecutive MEG recordings over 7 years, using two different MEG recordings systems; a 151-channel VSM-CTF system for the first two time points and a 306-channel Elekta Vectorview system for the third time point. We assessed the within (longitudinal) and between-subject (cross-sectional) consistency of power spectra and functional connectivity matrices. Consistency of within-subject spectral power and functional connectivity matrices was good and was not significantly different when using different MEG recording systems as compared to using the same system. Importantly, we confirmed that within-subject consistency values were higher than between-subject values. We demonstrated consistent neurophysiological findings in healthy subjects over a time span of seven years, despite using data recorded on different MEG systems and different implementations of the analysis pipeline.Lennard I. BoonPrejaas TewarieHenk W. BerendseCornelis J. StamArjan HillebrandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lennard I. Boon Prejaas Tewarie Henk W. Berendse Cornelis J. Stam Arjan Hillebrand Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
description	Abstract Longitudinal analyses of magnetoencephalography (MEG) data are essential for a full understanding of the pathophysiology of brain diseases and the development of brain activity over time. However, time-dependent factors, such as the recording environment and the type of MEG recording system may affect such longitudinal analyses. We hypothesized that, using source-space analysis, hardware and software differences between two recordings systems may be overcome, with the aim of finding consistent neurophysiological results. We studied eight healthy subjects who underwent three consecutive MEG recordings over 7 years, using two different MEG recordings systems; a 151-channel VSM-CTF system for the first two time points and a 306-channel Elekta Vectorview system for the third time point. We assessed the within (longitudinal) and between-subject (cross-sectional) consistency of power spectra and functional connectivity matrices. Consistency of within-subject spectral power and functional connectivity matrices was good and was not significantly different when using different MEG recording systems as compared to using the same system. Importantly, we confirmed that within-subject consistency values were higher than between-subject values. We demonstrated consistent neurophysiological findings in healthy subjects over a time span of seven years, despite using data recorded on different MEG systems and different implementations of the analysis pipeline.
format	article
author	Lennard I. Boon Prejaas Tewarie Henk W. Berendse Cornelis J. Stam Arjan Hillebrand
author_facet	Lennard I. Boon Prejaas Tewarie Henk W. Berendse Cornelis J. Stam Arjan Hillebrand
author_sort	Lennard I. Boon
title	Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
title_short	Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
title_full	Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
title_fullStr	Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
title_full_unstemmed	Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
title_sort	longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b443714be8d640a5bbe6d1d5c833c5a7
work_keys_str_mv	AT lennardiboon longitudinalconsistencyofsourcespacespectralpowerandfunctionalconnectivityusingdifferentmagnetoencephalographyrecordingsystems AT prejaastewarie longitudinalconsistencyofsourcespacespectralpowerandfunctionalconnectivityusingdifferentmagnetoencephalographyrecordingsystems AT henkwberendse longitudinalconsistencyofsourcespacespectralpowerandfunctionalconnectivityusingdifferentmagnetoencephalographyrecordingsystems AT cornelisjstam longitudinalconsistencyofsourcespacespectralpowerandfunctionalconnectivityusingdifferentmagnetoencephalographyrecordingsystems AT arjanhillebrand longitudinalconsistencyofsourcespacespectralpowerandfunctionalconnectivityusingdifferentmagnetoencephalographyrecordingsystems
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Longitudinal consistency of source-space spectral power and functional connectivity using different magnetoencephalography recording systems

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