Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation

Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quant...

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Autores principales:	Cincović Marko, Kirovski Danijela, Vujanac Ivan, Belić Branislava, Djoković Radojica
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	cows insulin resistance metabolic status early lactation Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b44794b8d83b41499ff51e3c398f5d9a
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spelling	oai:doaj.org-article:b44794b8d83b41499ff51e3c398f5d9a2021-11-17T21:27:51ZRelationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation1820-744810.1515/acve-2017-0006https://doaj.org/article/b44794b8d83b41499ff51e3c398f5d9a2017-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0006https://doaj.org/toc/1820-7448Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p<0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p<0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p<0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p<0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p<0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p<0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p<0.01), T4 (r=0.47, r2=22.1, b=87.142, p<0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p<0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p<0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p<0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p<0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p<0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p<0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process.Cincović MarkoKirovski DanijelaVujanac IvanBelić BranislavaDjoković RadojicaSciendoarticlecowsinsulin resistancemetabolic statusearly lactationVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 1, Pp 57-70 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cows insulin resistance metabolic status early lactation Veterinary medicine SF600-1100
spellingShingle	cows insulin resistance metabolic status early lactation Veterinary medicine SF600-1100 Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
description	Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p<0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p<0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p<0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p<0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p<0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p<0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p<0.01), T4 (r=0.47, r2=22.1, b=87.142, p<0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p<0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p<0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p<0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p<0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p<0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p<0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process.
format	article
author	Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica
author_facet	Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica
author_sort	Cincović Marko
title	Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
title_short	Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
title_full	Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
title_fullStr	Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
title_full_unstemmed	Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
title_sort	relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/b44794b8d83b41499ff51e3c398f5d9a
work_keys_str_mv	AT cincovicmarko relationshipbetweentheindexesofinsulinresistanceandmetabolicstatusindairycowsduringearlylactation AT kirovskidanijela relationshipbetweentheindexesofinsulinresistanceandmetabolicstatusindairycowsduringearlylactation AT vujanacivan relationshipbetweentheindexesofinsulinresistanceandmetabolicstatusindairycowsduringearlylactation AT belicbranislava relationshipbetweentheindexesofinsulinresistanceandmetabolicstatusindairycowsduringearlylactation AT djokovicradojica relationshipbetweentheindexesofinsulinresistanceandmetabolicstatusindairycowsduringearlylactation
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Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation

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