ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers

Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and prot...

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Autores principales:	Wei Wang, Mingqi Li, Suriyan Ponnusamy, Yayun Chi, Jingyan Xue, Beshoy Fahmy, Meiyun Fan, Gustavo A. Miranda-Carboni, Ramesh Narayanan, Jiong Wu, Zhao-Hui Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4496d310ec64236a21571f5bea2d9bf
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spelling	oai:doaj.org-article:b4496d310ec64236a21571f5bea2d9bf2021-12-02T14:53:37ZABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers10.1038/s41467-020-17770-92041-1723https://doaj.org/article/b4496d310ec64236a21571f5bea2d9bf2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17770-9https://doaj.org/toc/2041-1723Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and proteasomal degradation of β-catenin.Wei WangMingqi LiSuriyan PonnusamyYayun ChiJingyan XueBeshoy FahmyMeiyun FanGustavo A. Miranda-CarboniRamesh NarayananJiong WuZhao-Hui WuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
description	Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and proteasomal degradation of β-catenin.
format	article
author	Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu
author_facet	Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu
author_sort	Wei Wang
title	ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
title_short	ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
title_full	ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
title_fullStr	ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
title_full_unstemmed	ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
title_sort	abl1-dependent otulin phosphorylation promotes genotoxic wnt/β-catenin activation to enhance drug resistance in breast cancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4496d310ec64236a21571f5bea2d9bf
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ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers

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