The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs and Echinoid, which in turn are regulated by nutrie...

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Auteurs principaux:	Rouven Ding, Kevin Weynans, Torsten Bossing, Claudia S. Barros, Christian Berger
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b45130861d8047d4ad7b56043c0cb9b3
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id	oai:doaj.org-article:b45130861d8047d4ad7b56043c0cb9b3
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spelling	oai:doaj.org-article:b45130861d8047d4ad7b56043c0cb9b32021-12-02T16:50:14ZThe Hippo signalling pathway maintains quiescence in Drosophila neural stem cells10.1038/ncomms105102041-1723https://doaj.org/article/b45130861d8047d4ad7b56043c0cb9b32016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10510https://doaj.org/toc/2041-1723Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs and Echinoid, which in turn are regulated by nutrient levels.Rouven DingKevin WeynansTorsten BossingClaudia S. BarrosChristian BergerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rouven Ding Kevin Weynans Torsten Bossing Claudia S. Barros Christian Berger The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
description	Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs and Echinoid, which in turn are regulated by nutrient levels.
format	article
author	Rouven Ding Kevin Weynans Torsten Bossing Claudia S. Barros Christian Berger
author_facet	Rouven Ding Kevin Weynans Torsten Bossing Claudia S. Barros Christian Berger
author_sort	Rouven Ding
title	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
title_short	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
title_full	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
title_fullStr	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
title_full_unstemmed	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
title_sort	hippo signalling pathway maintains quiescence in drosophila neural stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b45130861d8047d4ad7b56043c0cb9b3
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The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

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