Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives

Ambaye Kenubih University of Gondar, College of Veterinary Medicine and Animal Sciences, Para-Clinical Studies, Gondar, EthiopiaCorrespondence: Ambaye Kenubih Email ambayken@yahoo.comAbstract: Foot and mouth disease (FMD) is an extremely contagious viral disease of livestock caused by foot and mouse...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Kenubih A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	fmd vaccine long last immunity sterile immunity Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b4562d7a30eb4ebc899018d135cfb89b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b4562d7a30eb4ebc899018d135cfb89b
record_format	dspace
spelling	oai:doaj.org-article:b4562d7a30eb4ebc899018d135cfb89b2021-12-02T15:12:56ZFoot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives2230-2034https://doaj.org/article/b4562d7a30eb4ebc899018d135cfb89b2021-09-01T00:00:00Zhttps://www.dovepress.com/foot-and-mouth-disease-vaccine-development-and-challenges-in-inducing--peer-reviewed-fulltext-article-VMRRhttps://doaj.org/toc/2230-2034Ambaye Kenubih University of Gondar, College of Veterinary Medicine and Animal Sciences, Para-Clinical Studies, Gondar, EthiopiaCorrespondence: Ambaye Kenubih Email ambayken@yahoo.comAbstract: Foot and mouth disease (FMD) is an extremely contagious viral disease of livestock caused by foot and mouse disease virus genus: Aphthovirus, which causes a serious economic impact on both individual farmers and the national economy. Many attempts to advance a vaccine for FMD have failed to induce sterile immunity. The classical methods of vaccine production were due to selective accumulation of mutations around antigenic and binding sites. Reversion of the agent by positive selection and quasi-species swarm, use of this method is inapplicable for use in non-endemic areas. Chemical attenuation using binary ethyleneimine (BEI) protected the capsid integrity and produced a pronounced immunity against the challenge strain. Viral antigens which have been chemically synthesized or expressed in viruses, plasmid, or plants were tried in the vaccination of animals. DNA vaccines expressing either structural or nonstructural protein antigens have been tried to immunize animals. Using interleukins as a genetic adjuvant for DNA vaccines have a promising effect. While the challenges of inducing sterile immunity lies on non-structural (NS) proteins of FMDV which are responsible for apoptosis of dendritic cells and have negative effects on lympho-proliferative responses which lead to transient immunosuppression. Furthermore, destruction of host protein trafficking by nonstructural proteins suppressed CD8+ T-cell proliferation. In this review, it tried to address multiple approaches for vaccine development trials and bottle necks of producing sterile immunity.Keywords: FMD vaccine, long lasting immunity, sterile immunityKenubih ADove Medical Pressarticlefmd vaccinelong last immunitysterile immunityVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 12, Pp 205-215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fmd vaccine long last immunity sterile immunity Veterinary medicine SF600-1100
spellingShingle	fmd vaccine long last immunity sterile immunity Veterinary medicine SF600-1100 Kenubih A Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
description	Ambaye Kenubih University of Gondar, College of Veterinary Medicine and Animal Sciences, Para-Clinical Studies, Gondar, EthiopiaCorrespondence: Ambaye Kenubih Email ambayken@yahoo.comAbstract: Foot and mouth disease (FMD) is an extremely contagious viral disease of livestock caused by foot and mouse disease virus genus: Aphthovirus, which causes a serious economic impact on both individual farmers and the national economy. Many attempts to advance a vaccine for FMD have failed to induce sterile immunity. The classical methods of vaccine production were due to selective accumulation of mutations around antigenic and binding sites. Reversion of the agent by positive selection and quasi-species swarm, use of this method is inapplicable for use in non-endemic areas. Chemical attenuation using binary ethyleneimine (BEI) protected the capsid integrity and produced a pronounced immunity against the challenge strain. Viral antigens which have been chemically synthesized or expressed in viruses, plasmid, or plants were tried in the vaccination of animals. DNA vaccines expressing either structural or nonstructural protein antigens have been tried to immunize animals. Using interleukins as a genetic adjuvant for DNA vaccines have a promising effect. While the challenges of inducing sterile immunity lies on non-structural (NS) proteins of FMDV which are responsible for apoptosis of dendritic cells and have negative effects on lympho-proliferative responses which lead to transient immunosuppression. Furthermore, destruction of host protein trafficking by nonstructural proteins suppressed CD8+ T-cell proliferation. In this review, it tried to address multiple approaches for vaccine development trials and bottle necks of producing sterile immunity.Keywords: FMD vaccine, long lasting immunity, sterile immunity
format	article
author	Kenubih A
author_facet	Kenubih A
author_sort	Kenubih A
title	Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
title_short	Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
title_full	Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
title_fullStr	Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
title_full_unstemmed	Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives
title_sort	foot and mouth disease vaccine development and challenges in inducing long-lasting immunity: trends and current perspectives
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b4562d7a30eb4ebc899018d135cfb89b
work_keys_str_mv	AT kenubiha footandmouthdiseasevaccinedevelopmentandchallengesininducinglonglastingimmunitytrendsandcurrentperspectives
_version_	1718387653597986816

Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives

Ejemplares similares