Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient

Kailiang Wang,1,2 Qi Chai,1 Hui Qiao,1 Jianguo Zhang,2,3 Tinghong Liu,1,2 Fangang Meng,1,2 1Beijing Neurosurgical Institute, Capital Medical University, 2Beijing Key Laboratory of Neurostimulation, 3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People&am...

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Autores principales:	Wang KL, Chai Q, Qiao H, Zhang JG, Liu TH, Meng FG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	vagus nerve stimulation epilepsy monitoring epilepsy surgery functional neuroimaging brain network balance. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b45677e4cde14014a3fbd57528d546e8
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spelling	oai:doaj.org-article:b45677e4cde14014a3fbd57528d546e82021-12-02T00:43:17ZVagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient1178-2021https://doaj.org/article/b45677e4cde14014a3fbd57528d546e82016-10-01T00:00:00Zhttps://www.dovepress.com/vagus-nerve-stimulation-balanced-disrupted-default-mode-network-and-sa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kailiang Wang,1,2 Qi Chai,1 Hui Qiao,1 Jianguo Zhang,2,3 Tinghong Liu,1,2 Fangang Meng,1,2 1Beijing Neurosurgical Institute, Capital Medical University, 2Beijing Key Laboratory of Neurostimulation, 3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Introduction: In recent years, treatment of intractable epilepsy has become more challenging, due to an increase in resistance to antiepileptic drugs, as well as diminished success following resection surgery. Here, we present the case of a 19-year old epileptic patient who received vagus nerve stimulation (VNS) following unsuccessful left parietal–occipital lesion-resection surgery, with results indicating an approximate 50% reduction in seizure frequency and a much longer seizure-free interictal phase. Materials and methods: Using resting-state functional magnetic resonance imaging, we measured the changes in resting-state brain networks between pre-VNS treatment and 6 months post-VNS, from the perspective of regional and global variations, using regional homogeneity and large-scale functional connectives (seeding posterior cingulate cortex and anterior cingulate cortex), respectively. Results: After 6 months of VNS therapy, the resting-state brain networks were slightly reorganized in regional homogeneity, mainly in large-scale functional connectivity, where excessive activation of the salience network was suppressed, while at the same time the suppressed default-mode network was activated. Conclusion: With regard to resting-state brain networks, we propose a hypothesis based on this single case study that VNS acts on intractable epilepsy by modulating the balance between salience and default-mode networks through the integral hub of the anterior cingulate cortex. Keywords: vagus nerve stimulation, epilepsy monitoring, epilepsy surgery, functional neuroimaging, brain-network balanceWang KLChai QQiao HZhang JGLiu THMeng FGDove Medical Pressarticlevagus nerve stimulationepilepsy monitoringepilepsy surgeryfunctional neuroimagingbrain network balance.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2561-2571 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	vagus nerve stimulation epilepsy monitoring epilepsy surgery functional neuroimaging brain network balance. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	vagus nerve stimulation epilepsy monitoring epilepsy surgery functional neuroimaging brain network balance. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang KL Chai Q Qiao H Zhang JG Liu TH Meng FG Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
description	Kailiang Wang,1,2 Qi Chai,1 Hui Qiao,1 Jianguo Zhang,2,3 Tinghong Liu,1,2 Fangang Meng,1,2 1Beijing Neurosurgical Institute, Capital Medical University, 2Beijing Key Laboratory of Neurostimulation, 3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Introduction: In recent years, treatment of intractable epilepsy has become more challenging, due to an increase in resistance to antiepileptic drugs, as well as diminished success following resection surgery. Here, we present the case of a 19-year old epileptic patient who received vagus nerve stimulation (VNS) following unsuccessful left parietal–occipital lesion-resection surgery, with results indicating an approximate 50% reduction in seizure frequency and a much longer seizure-free interictal phase. Materials and methods: Using resting-state functional magnetic resonance imaging, we measured the changes in resting-state brain networks between pre-VNS treatment and 6 months post-VNS, from the perspective of regional and global variations, using regional homogeneity and large-scale functional connectives (seeding posterior cingulate cortex and anterior cingulate cortex), respectively. Results: After 6 months of VNS therapy, the resting-state brain networks were slightly reorganized in regional homogeneity, mainly in large-scale functional connectivity, where excessive activation of the salience network was suppressed, while at the same time the suppressed default-mode network was activated. Conclusion: With regard to resting-state brain networks, we propose a hypothesis based on this single case study that VNS acts on intractable epilepsy by modulating the balance between salience and default-mode networks through the integral hub of the anterior cingulate cortex. Keywords: vagus nerve stimulation, epilepsy monitoring, epilepsy surgery, functional neuroimaging, brain-network balance
format	article
author	Wang KL Chai Q Qiao H Zhang JG Liu TH Meng FG
author_facet	Wang KL Chai Q Qiao H Zhang JG Liu TH Meng FG
author_sort	Wang KL
title	Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
title_short	Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
title_full	Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
title_fullStr	Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
title_full_unstemmed	Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
title_sort	vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b45677e4cde14014a3fbd57528d546e8
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Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient

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