Optogenetic control of cellular forces and mechanotransduction

Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear localization, whereas directing it to the mitocho...

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Autores principales:	Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras, Xavier Trepat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4570ceae15042e68261e70dbdfbf737
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spelling	oai:doaj.org-article:b4570ceae15042e68261e70dbdfbf7372021-12-02T14:41:21ZOptogenetic control of cellular forces and mechanotransduction10.1038/ncomms143962041-1723https://doaj.org/article/b4570ceae15042e68261e70dbdfbf7372017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14396https://doaj.org/toc/2041-1723Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear localization, whereas directing it to the mitochondria causes relaxation.Léo ValonAriadna Marín-LlauradóThomas WyattGuillaume CharrasXavier TrepatNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Léo Valon Ariadna Marín-Llauradó Thomas Wyatt Guillaume Charras Xavier Trepat Optogenetic control of cellular forces and mechanotransduction
description	Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear localization, whereas directing it to the mitochondria causes relaxation.
format	article
author	Léo Valon Ariadna Marín-Llauradó Thomas Wyatt Guillaume Charras Xavier Trepat
author_facet	Léo Valon Ariadna Marín-Llauradó Thomas Wyatt Guillaume Charras Xavier Trepat
author_sort	Léo Valon
title	Optogenetic control of cellular forces and mechanotransduction
title_short	Optogenetic control of cellular forces and mechanotransduction
title_full	Optogenetic control of cellular forces and mechanotransduction
title_fullStr	Optogenetic control of cellular forces and mechanotransduction
title_full_unstemmed	Optogenetic control of cellular forces and mechanotransduction
title_sort	optogenetic control of cellular forces and mechanotransduction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b4570ceae15042e68261e70dbdfbf737
work_keys_str_mv	AT leovalon optogeneticcontrolofcellularforcesandmechanotransduction AT ariadnamarinllaurado optogeneticcontrolofcellularforcesandmechanotransduction AT thomaswyatt optogeneticcontrolofcellularforcesandmechanotransduction AT guillaumecharras optogeneticcontrolofcellularforcesandmechanotransduction AT xaviertrepat optogeneticcontrolofcellularforcesandmechanotransduction
_version_	1718389955153100800

Optogenetic control of cellular forces and mechanotransduction

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