Siah2 control of T-regulatory cells limits anti-tumor immunity

The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of t...

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Autores principales:	Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4571c9b4e094486a2056a1668569d65
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spelling	oai:doaj.org-article:b4571c9b4e094486a2056a1668569d652021-12-02T15:39:21ZSiah2 control of T-regulatory cells limits anti-tumor immunity10.1038/s41467-019-13826-72041-1723https://doaj.org/article/b4571c9b4e094486a2056a1668569d652020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13826-7https://doaj.org/toc/2041-1723The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of tumour growth.Marzia ScortegagnaKathryn HockemeyerIgor DolgalevJoanna PoźniakFlorian RambowYan LiYongmei FengRoberto TinocoDennis C. OteroTongwu ZhangKevin BrownMarcus BosenbergLinda M. BradleyJean-Christophe MarineIoannis AifantisZe’ev A. RonaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marzia Scortegagna Kathryn Hockemeyer Igor Dolgalev Joanna Poźniak Florian Rambow Yan Li Yongmei Feng Roberto Tinoco Dennis C. Otero Tongwu Zhang Kevin Brown Marcus Bosenberg Linda M. Bradley Jean-Christophe Marine Ioannis Aifantis Ze’ev A. Ronai Siah2 control of T-regulatory cells limits anti-tumor immunity
description	The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of tumour growth.
format	article
author	Marzia Scortegagna Kathryn Hockemeyer Igor Dolgalev Joanna Poźniak Florian Rambow Yan Li Yongmei Feng Roberto Tinoco Dennis C. Otero Tongwu Zhang Kevin Brown Marcus Bosenberg Linda M. Bradley Jean-Christophe Marine Ioannis Aifantis Ze’ev A. Ronai
author_facet	Marzia Scortegagna Kathryn Hockemeyer Igor Dolgalev Joanna Poźniak Florian Rambow Yan Li Yongmei Feng Roberto Tinoco Dennis C. Otero Tongwu Zhang Kevin Brown Marcus Bosenberg Linda M. Bradley Jean-Christophe Marine Ioannis Aifantis Ze’ev A. Ronai
author_sort	Marzia Scortegagna
title	Siah2 control of T-regulatory cells limits anti-tumor immunity
title_short	Siah2 control of T-regulatory cells limits anti-tumor immunity
title_full	Siah2 control of T-regulatory cells limits anti-tumor immunity
title_fullStr	Siah2 control of T-regulatory cells limits anti-tumor immunity
title_full_unstemmed	Siah2 control of T-regulatory cells limits anti-tumor immunity
title_sort	siah2 control of t-regulatory cells limits anti-tumor immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4571c9b4e094486a2056a1668569d65
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Siah2 control of T-regulatory cells limits anti-tumor immunity

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