Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

Abstract Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosyno...

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Autores principales:	Byung Joo Lee, Kihwang Lee, Seung Ah Chung, Hyun Taek Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b45b67fa1ea44e2e9285b04275d75e9b
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spelling	oai:doaj.org-article:b45b67fa1ea44e2e9285b04275d75e9b2021-12-02T16:31:17ZOcular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis10.1038/s41598-021-85620-92045-2322https://doaj.org/article/b45b67fa1ea44e2e9285b04275d75e9b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85620-9https://doaj.org/toc/2045-2322Abstract Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 ± 2.51 (range, 4–16) years and mean spherical equivalent was -0.09 ± 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (p < 0.01, p < 0.01, and p < 0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.Byung Joo LeeKihwang LeeSeung Ah ChungHyun Taek LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Byung Joo Lee Kihwang Lee Seung Ah Chung Hyun Taek Lim Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
description	Abstract Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 ± 2.51 (range, 4–16) years and mean spherical equivalent was -0.09 ± 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (p < 0.01, p < 0.01, and p < 0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.
format	article
author	Byung Joo Lee Kihwang Lee Seung Ah Chung Hyun Taek Lim
author_facet	Byung Joo Lee Kihwang Lee Seung Ah Chung Hyun Taek Lim
author_sort	Byung Joo Lee
title	Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
title_short	Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
title_full	Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
title_fullStr	Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
title_full_unstemmed	Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
title_sort	ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b45b67fa1ea44e2e9285b04275d75e9b
work_keys_str_mv	AT byungjoolee ocularbiometricfeaturesofpediatricpatientswithfibroblastgrowthfactorreceptorrelatedsyndromiccraniosynostosis AT kihwanglee ocularbiometricfeaturesofpediatricpatientswithfibroblastgrowthfactorreceptorrelatedsyndromiccraniosynostosis AT seungahchung ocularbiometricfeaturesofpediatricpatientswithfibroblastgrowthfactorreceptorrelatedsyndromiccraniosynostosis AT hyuntaeklim ocularbiometricfeaturesofpediatricpatientswithfibroblastgrowthfactorreceptorrelatedsyndromiccraniosynostosis
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Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

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