Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

Cellular senescence is a cell fate primarily induced by DNA damage, characterized by irreversible growth arrest in an attempt to stop the damage. Senescence is a cellular response to a stressor and is observed with aging, but also during wound healing and in embryogenic developmental processes. Sene...

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Autores principales:	Nathalie Thorin-Trescases, Pauline Labbé, Pauline Mury, Mélanie Lambert, Eric Thorin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	programmed senescence senescence angiopoietin-like 2 biomarker age-related diseases Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b45b6c2e3e5c4052a0edc237be639f16
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spelling	oai:doaj.org-article:b45b6c2e3e5c4052a0edc237be639f162021-11-25T17:54:32ZAngptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence10.3390/ijms2222122321422-00671661-6596https://doaj.org/article/b45b6c2e3e5c4052a0edc237be639f162021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12232https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cellular senescence is a cell fate primarily induced by DNA damage, characterized by irreversible growth arrest in an attempt to stop the damage. Senescence is a cellular response to a stressor and is observed with aging, but also during wound healing and in embryogenic developmental processes. Senescent cells are metabolically active and secrete a multitude of molecules gathered in the senescence-associated secretory phenotype (SASP). The SASP includes inflammatory cytokines, chemokines, growth factors and metalloproteinases, with autocrine and paracrine activities. Among hundreds of molecules, angiopoietin-like 2 (angptl2) is an interesting, although understudied, SASP member identified in various types of senescent cells. Angptl2 is a circulatory protein, and plasma angptl2 levels increase with age and with various chronic inflammatory diseases such as cancer, atherosclerosis, diabetes, heart failure and a multitude of age-related diseases. In this review, we will examine in which context angptl2 was identified as a SASP factor, describe the experimental evidence showing that angptl2 is a marker of senescence in vitro and in vivo, and discuss the impact of angptl2-related senescence in both physiological and pathological conditions. Future work is needed to demonstrate whether the senescence marker angptl2 is a potential clinical biomarker of age-related diseases.Nathalie Thorin-TrescasesPauline LabbéPauline MuryMélanie LambertEric ThorinMDPI AGarticleprogrammed senescencesenescenceangiopoietin-like 2biomarkerage-related diseasesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12232, p 12232 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	programmed senescence senescence angiopoietin-like 2 biomarker age-related diseases Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	programmed senescence senescence angiopoietin-like 2 biomarker age-related diseases Biology (General) QH301-705.5 Chemistry QD1-999 Nathalie Thorin-Trescases Pauline Labbé Pauline Mury Mélanie Lambert Eric Thorin Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
description	Cellular senescence is a cell fate primarily induced by DNA damage, characterized by irreversible growth arrest in an attempt to stop the damage. Senescence is a cellular response to a stressor and is observed with aging, but also during wound healing and in embryogenic developmental processes. Senescent cells are metabolically active and secrete a multitude of molecules gathered in the senescence-associated secretory phenotype (SASP). The SASP includes inflammatory cytokines, chemokines, growth factors and metalloproteinases, with autocrine and paracrine activities. Among hundreds of molecules, angiopoietin-like 2 (angptl2) is an interesting, although understudied, SASP member identified in various types of senescent cells. Angptl2 is a circulatory protein, and plasma angptl2 levels increase with age and with various chronic inflammatory diseases such as cancer, atherosclerosis, diabetes, heart failure and a multitude of age-related diseases. In this review, we will examine in which context angptl2 was identified as a SASP factor, describe the experimental evidence showing that angptl2 is a marker of senescence in vitro and in vivo, and discuss the impact of angptl2-related senescence in both physiological and pathological conditions. Future work is needed to demonstrate whether the senescence marker angptl2 is a potential clinical biomarker of age-related diseases.
format	article
author	Nathalie Thorin-Trescases Pauline Labbé Pauline Mury Mélanie Lambert Eric Thorin
author_facet	Nathalie Thorin-Trescases Pauline Labbé Pauline Mury Mélanie Lambert Eric Thorin
author_sort	Nathalie Thorin-Trescases
title	Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
title_short	Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
title_full	Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
title_fullStr	Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
title_full_unstemmed	Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
title_sort	angptl2 is a marker of cellular senescence: the physiological and pathophysiological impact of angptl2-related senescence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b45b6c2e3e5c4052a0edc237be639f16
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Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

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