The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease

Abstract Vulnerability to stress-induced inflammation has been linked to a dysfunctional hypothalamus–pituitary–adrenal (HPA) axis. In the present study, patients with known or suspected coronary artery disease (CAD) were assessed with respect to inflammatory and HPA axis response to acute physical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zeid Mahmood, Anette Davidsson, Eva Olsson, Per Leanderson, Anna K. Lundberg, Lena Jonasson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b45b77ef90ad452da227840edf81b03c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b45b77ef90ad452da227840edf81b03c
record_format	dspace
spelling	oai:doaj.org-article:b45b77ef90ad452da227840edf81b03c2021-12-02T15:09:22ZThe effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease10.1038/s41598-020-78286-22045-2322https://doaj.org/article/b45b77ef90ad452da227840edf81b03c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78286-2https://doaj.org/toc/2045-2322Abstract Vulnerability to stress-induced inflammation has been linked to a dysfunctional hypothalamus–pituitary–adrenal (HPA) axis. In the present study, patients with known or suspected coronary artery disease (CAD) were assessed with respect to inflammatory and HPA axis response to acute physical exercise. An exercise stress test was combined with SPECT myocardial perfusion imaging. Plasma and saliva samples were collected before and 30 min after exercise. Interleukin (IL)-6 and adrenocorticotropic hormone (ACTH) were measured in plasma, while cortisol was measured in both plasma and saliva. In total, 124 patients were included of whom 29% had a prior history of CAD and/or a myocardial perfusion deficit. The levels of exercise intensity and duration were comparable in CAD and non-CAD patients. However, in CAD patients, IL-6 increased after exercise (p = 0.019) while no differences were seen in HPA axis variables. Conversely, patients without CAD exhibited increased levels of ACTH (p = 0.003) and cortisol (p = 0.004 in plasma, p = 0.006 in saliva), but no change in IL-6. We conclude that the IL-6 response to acute physical exercise is exaggerated in CAD patients and may be out of balance due to HPA axis hypoactivity. It remains to be further investigated whether this imbalance is a potential diagnostic and therapeutic target in CAD.Zeid MahmoodAnette DavidssonEva OlssonPer LeandersonAnna K. LundbergLena JonassonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zeid Mahmood Anette Davidsson Eva Olsson Per Leanderson Anna K. Lundberg Lena Jonasson The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
description	Abstract Vulnerability to stress-induced inflammation has been linked to a dysfunctional hypothalamus–pituitary–adrenal (HPA) axis. In the present study, patients with known or suspected coronary artery disease (CAD) were assessed with respect to inflammatory and HPA axis response to acute physical exercise. An exercise stress test was combined with SPECT myocardial perfusion imaging. Plasma and saliva samples were collected before and 30 min after exercise. Interleukin (IL)-6 and adrenocorticotropic hormone (ACTH) were measured in plasma, while cortisol was measured in both plasma and saliva. In total, 124 patients were included of whom 29% had a prior history of CAD and/or a myocardial perfusion deficit. The levels of exercise intensity and duration were comparable in CAD and non-CAD patients. However, in CAD patients, IL-6 increased after exercise (p = 0.019) while no differences were seen in HPA axis variables. Conversely, patients without CAD exhibited increased levels of ACTH (p = 0.003) and cortisol (p = 0.004 in plasma, p = 0.006 in saliva), but no change in IL-6. We conclude that the IL-6 response to acute physical exercise is exaggerated in CAD patients and may be out of balance due to HPA axis hypoactivity. It remains to be further investigated whether this imbalance is a potential diagnostic and therapeutic target in CAD.
format	article
author	Zeid Mahmood Anette Davidsson Eva Olsson Per Leanderson Anna K. Lundberg Lena Jonasson
author_facet	Zeid Mahmood Anette Davidsson Eva Olsson Per Leanderson Anna K. Lundberg Lena Jonasson
author_sort	Zeid Mahmood
title	The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
title_short	The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
title_full	The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
title_fullStr	The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
title_full_unstemmed	The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
title_sort	effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b45b77ef90ad452da227840edf81b03c
work_keys_str_mv	AT zeidmahmood theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT anettedavidsson theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT evaolsson theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT perleanderson theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT annaklundberg theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT lenajonasson theeffectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT zeidmahmood effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT anettedavidsson effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT evaolsson effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT perleanderson effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT annaklundberg effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease AT lenajonasson effectofacuteexerciseoninterleukin6andhypothalamicpituitaryadrenalaxisresponsesinpatientswithcoronaryarterydisease
_version_	1718387834115588096

The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease

Ejemplares similares