The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?

microRNA are noncoding endogenous RNAs of ∼ 25-nucleotide, involved in RNA silencing and controlling of cell function. Recent evidence has highlighted the important role of various in the biology of human cancers. miR-9 is a highly conserved microRNA and abnormal regulation of miR-9 expression has v...

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Autores principales:	Afsane Bahrami, Amirsajad Jafari, Gordon A. Ferns
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cyclin D1 CXCR-4 CDX2 Colorectal cancer LncRNA Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b45f410f9d064596b4bb80ef7523841a
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spelling	oai:doaj.org-article:b45f410f9d064596b4bb80ef7523841a2021-11-14T04:30:28ZThe dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?0753-332210.1016/j.biopha.2021.112394https://doaj.org/article/b45f410f9d064596b4bb80ef7523841a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S075333222101180Xhttps://doaj.org/toc/0753-3322microRNA are noncoding endogenous RNAs of ∼ 25-nucleotide, involved in RNA silencing and controlling of cell function. Recent evidence has highlighted the important role of various in the biology of human cancers. miR-9 is a highly conserved microRNA and abnormal regulation of miR-9 expression has various impacts on disease pathology. miR-9 may play a dual tumor-suppressive or oncomiR activity in several cancers. There have been conflicting reports concerning the role of miR-9 in gastrointestinal cancers. Several signaling pathways including PDK/AKT, Hippo, Wnt/β-catenin and PDGFRB axes are affected by miR-9 in suppressing proliferation, invasion and metastasis of tumor cells. Oncogenic miR-9 triggers migration, metastasis and clinic-pathological characteristics of patients with gastrointestinal malignancy by targeting various enzymes and transcription factors such as E-cadherin, HK2, LMX1A, and CDX2. On the other hand, long non-coding RNAs and circular RNAs can modulate miR-9 expression in human cancers. In this review, we aimed to summarize recent findings about the potential value of miR-9 in gastrointestinal tumors, that include: screening, prognostic and treatment.Afsane BahramiAmirsajad JafariGordon A. FernsElsevierarticleCyclin D1CXCR-4CDX2Colorectal cancerLncRNATherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112394- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cyclin D1 CXCR-4 CDX2 Colorectal cancer LncRNA Therapeutics. Pharmacology RM1-950
spellingShingle	Cyclin D1 CXCR-4 CDX2 Colorectal cancer LncRNA Therapeutics. Pharmacology RM1-950 Afsane Bahrami Amirsajad Jafari Gordon A. Ferns The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
description	microRNA are noncoding endogenous RNAs of ∼ 25-nucleotide, involved in RNA silencing and controlling of cell function. Recent evidence has highlighted the important role of various in the biology of human cancers. miR-9 is a highly conserved microRNA and abnormal regulation of miR-9 expression has various impacts on disease pathology. miR-9 may play a dual tumor-suppressive or oncomiR activity in several cancers. There have been conflicting reports concerning the role of miR-9 in gastrointestinal cancers. Several signaling pathways including PDK/AKT, Hippo, Wnt/β-catenin and PDGFRB axes are affected by miR-9 in suppressing proliferation, invasion and metastasis of tumor cells. Oncogenic miR-9 triggers migration, metastasis and clinic-pathological characteristics of patients with gastrointestinal malignancy by targeting various enzymes and transcription factors such as E-cadherin, HK2, LMX1A, and CDX2. On the other hand, long non-coding RNAs and circular RNAs can modulate miR-9 expression in human cancers. In this review, we aimed to summarize recent findings about the potential value of miR-9 in gastrointestinal tumors, that include: screening, prognostic and treatment.
format	article
author	Afsane Bahrami Amirsajad Jafari Gordon A. Ferns
author_facet	Afsane Bahrami Amirsajad Jafari Gordon A. Ferns
author_sort	Afsane Bahrami
title	The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
title_short	The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
title_full	The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
title_fullStr	The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
title_full_unstemmed	The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?
title_sort	dual role of microrna-9 in gastrointestinal cancers: oncomir or tumor suppressor?
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/b45f410f9d064596b4bb80ef7523841a
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The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?

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