Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Constitutive deletion of Rcan1 has been previously shown to prevent Angiotensin II-induced aneurysm in mice. Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to in...

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Autores principales:	Silvia Villahoz, Paula Sofía Yunes-Leites, Nerea Méndez-Barbero, Katia Urso, Elena Bonzon-Kulichenko, Sagrario Ortega, J. Francisco Nistal, Jesus Vazquez, Stefan Offermanns, Juan Miguel Redondo, Miguel R. Campanero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b45f5a6013db43deb6951e882842b7d3
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spelling	oai:doaj.org-article:b45f5a6013db43deb6951e882842b7d32021-12-02T16:49:20ZConditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture10.1038/s41467-018-07071-72041-1723https://doaj.org/article/b45f5a6013db43deb6951e882842b7d32018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07071-7https://doaj.org/toc/2041-1723Constitutive deletion of Rcan1 has been previously shown to prevent Angiotensin II-induced aneurysm in mice. Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to increased GSK-3b-mediated activation of ROCK and induction of a hypercontractile phenotype.Silvia VillahozPaula Sofía Yunes-LeitesNerea Méndez-BarberoKatia UrsoElena Bonzon-KulichenkoSagrario OrtegaJ. Francisco NistalJesus VazquezStefan OffermannsJuan Miguel RedondoMiguel R. CampaneroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Villahoz Paula Sofía Yunes-Leites Nerea Méndez-Barbero Katia Urso Elena Bonzon-Kulichenko Sagrario Ortega J. Francisco Nistal Jesus Vazquez Stefan Offermanns Juan Miguel Redondo Miguel R. Campanero Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
description	Constitutive deletion of Rcan1 has been previously shown to prevent Angiotensin II-induced aneurysm in mice. Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to increased GSK-3b-mediated activation of ROCK and induction of a hypercontractile phenotype.
format	article
author	Silvia Villahoz Paula Sofía Yunes-Leites Nerea Méndez-Barbero Katia Urso Elena Bonzon-Kulichenko Sagrario Ortega J. Francisco Nistal Jesus Vazquez Stefan Offermanns Juan Miguel Redondo Miguel R. Campanero
author_facet	Silvia Villahoz Paula Sofía Yunes-Leites Nerea Méndez-Barbero Katia Urso Elena Bonzon-Kulichenko Sagrario Ortega J. Francisco Nistal Jesus Vazquez Stefan Offermanns Juan Miguel Redondo Miguel R. Campanero
author_sort	Silvia Villahoz
title	Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
title_short	Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
title_full	Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
title_fullStr	Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
title_full_unstemmed	Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
title_sort	conditional deletion of rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b45f5a6013db43deb6951e882842b7d3
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Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

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