BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability

The genomic instability phenotype characteristic of BRCA2-deficient cells is not fully mechanistically understood. Here the authors show BRCA2 inactivation destabilizes RPA-coated single-stranded DNA and leads to toxic non homologous end-joining events.

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Autores principales:	Jinhua Han, Chunyan Ruan, Michael S. Y. Huen, Jiadong Wang, Anyong Xie, Chun Fu, Ting Liu, Jun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b460e0da0ea64118a5802381662c288d
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spelling	oai:doaj.org-article:b460e0da0ea64118a5802381662c288d2021-12-02T14:42:09ZBRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability10.1038/s41467-017-01759-y2041-1723https://doaj.org/article/b460e0da0ea64118a5802381662c288d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01759-yhttps://doaj.org/toc/2041-1723The genomic instability phenotype characteristic of BRCA2-deficient cells is not fully mechanistically understood. Here the authors show BRCA2 inactivation destabilizes RPA-coated single-stranded DNA and leads to toxic non homologous end-joining events.Jinhua HanChunyan RuanMichael S. Y. HuenJiadong WangAnyong XieChun FuTing LiuJun HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinhua Han Chunyan Ruan Michael S. Y. Huen Jiadong Wang Anyong Xie Chun Fu Ting Liu Jun Huang BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
description	The genomic instability phenotype characteristic of BRCA2-deficient cells is not fully mechanistically understood. Here the authors show BRCA2 inactivation destabilizes RPA-coated single-stranded DNA and leads to toxic non homologous end-joining events.
format	article
author	Jinhua Han Chunyan Ruan Michael S. Y. Huen Jiadong Wang Anyong Xie Chun Fu Ting Liu Jun Huang
author_facet	Jinhua Han Chunyan Ruan Michael S. Y. Huen Jiadong Wang Anyong Xie Chun Fu Ting Liu Jun Huang
author_sort	Jinhua Han
title	BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
title_short	BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
title_full	BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
title_fullStr	BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
title_full_unstemmed	BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
title_sort	brca2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b460e0da0ea64118a5802381662c288d
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BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability

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