BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability

BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability

The genomic instability phenotype characteristic of BRCA2-deficient cells is not fully mechanistically understood. Here the authors show BRCA2 inactivation destabilizes RPA-coated single-stranded DNA and leads to toxic non homologous end-joining events.

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Autores principales: Jinhua Han, Chunyan Ruan, Michael S. Y. Huen, Jiadong Wang, Anyong Xie, Chun Fu, Ting Liu, Jun Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/b460e0da0ea64118a5802381662c288d
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