CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.

Uveal melanoma (UVM), the most common primary intraocular malignancy, has a high mortality because of a high propensity to metastasize. Our study analyzed prognostic value and immune-related characteristics of CARD11 in UVM, hoping to provide a potential management and research direction. The RNA-se...

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Autores principales:	Xueying Shi, Shilin Xia, Yingming Chu, Nan Yang, Jingyuan Zheng, Qianyi Chen, Zeng Fen, Yuankuan Jiang, Shifeng Fang, Jingrong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b466d864045d41ea9bb9fb66b2ab48ba
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spelling	oai:doaj.org-article:b466d864045d41ea9bb9fb66b2ab48ba2021-12-02T20:18:30ZCARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.1932-620310.1371/journal.pone.0255293https://doaj.org/article/b466d864045d41ea9bb9fb66b2ab48ba2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255293https://doaj.org/toc/1932-6203Uveal melanoma (UVM), the most common primary intraocular malignancy, has a high mortality because of a high propensity to metastasize. Our study analyzed prognostic value and immune-related characteristics of CARD11 in UVM, hoping to provide a potential management and research direction. The RNA-sequence data of 80 UVM patients were downloaded from The Cancer Genome Atlas database and divided them into high- and low-expression groups. We analyzed the differentially expressed genes, enrichment analyses and the infiltration of immune cells using the R package and Gene-Set Enrichment Analysis. A clinical prediction nomogram and protein-protein interaction network were constructed and the first 8 genes were considered as the hub-genes. Finally, we constructed a competing endogenous RNA (ceRNA) network by Cytoscape and analyzed the statistical data via the R software. Here we found that CARD11 expression had notable correlation with UVM clinicopathological features, which was also an independent predictor for overall survival (OS). Intriguingly, CARD11 had a positively correlation to autophagy, cellular senescence and apoptosis. Infiltration of monocytes was significantly higher in low CARD11 expression group, and infiltration of T cells regulatory was lower in the same group. Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA. These findings show that high CARD11 expression in UVM is associated with poor OS, indicating that CARD11 may serve as a potential biomarker for the diagnosis and prognosis of the UVM.Xueying ShiShilin XiaYingming ChuNan YangJingyuan ZhengQianyi ChenZeng FenYuankuan JiangShifeng FangJingrong LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255293 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueying Shi Shilin Xia Yingming Chu Nan Yang Jingyuan Zheng Qianyi Chen Zeng Fen Yuankuan Jiang Shifeng Fang Jingrong Lin CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
description	Uveal melanoma (UVM), the most common primary intraocular malignancy, has a high mortality because of a high propensity to metastasize. Our study analyzed prognostic value and immune-related characteristics of CARD11 in UVM, hoping to provide a potential management and research direction. The RNA-sequence data of 80 UVM patients were downloaded from The Cancer Genome Atlas database and divided them into high- and low-expression groups. We analyzed the differentially expressed genes, enrichment analyses and the infiltration of immune cells using the R package and Gene-Set Enrichment Analysis. A clinical prediction nomogram and protein-protein interaction network were constructed and the first 8 genes were considered as the hub-genes. Finally, we constructed a competing endogenous RNA (ceRNA) network by Cytoscape and analyzed the statistical data via the R software. Here we found that CARD11 expression had notable correlation with UVM clinicopathological features, which was also an independent predictor for overall survival (OS). Intriguingly, CARD11 had a positively correlation to autophagy, cellular senescence and apoptosis. Infiltration of monocytes was significantly higher in low CARD11 expression group, and infiltration of T cells regulatory was lower in the same group. Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA. These findings show that high CARD11 expression in UVM is associated with poor OS, indicating that CARD11 may serve as a potential biomarker for the diagnosis and prognosis of the UVM.
format	article
author	Xueying Shi Shilin Xia Yingming Chu Nan Yang Jingyuan Zheng Qianyi Chen Zeng Fen Yuankuan Jiang Shifeng Fang Jingrong Lin
author_facet	Xueying Shi Shilin Xia Yingming Chu Nan Yang Jingyuan Zheng Qianyi Chen Zeng Fen Yuankuan Jiang Shifeng Fang Jingrong Lin
author_sort	Xueying Shi
title	CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
title_short	CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
title_full	CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
title_fullStr	CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
title_full_unstemmed	CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
title_sort	card11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b466d864045d41ea9bb9fb66b2ab48ba
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CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.

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