Bone conducted responses in the neonatal rat auditory cortex

Abstract Rats are born deaf and start hearing at the end of the second postnatal week, when the ear canals open and low-intensity sounds start to evoke responses in the auditory cortex. Here, using μECoG electrode arrays and intracortical silicon probe recordings, we found that bone-conducted (BC) s...

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Autores principales:	Roman Makarov, Mikhail Sintsov, Guzel Valeeva, Pavel Starikov, Dmitriy Negrov, Roustem Khazipov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4679469fa4b492aa886e8bd05ddfb28
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spelling	oai:doaj.org-article:b4679469fa4b492aa886e8bd05ddfb282021-12-02T15:10:39ZBone conducted responses in the neonatal rat auditory cortex10.1038/s41598-021-96188-92045-2322https://doaj.org/article/b4679469fa4b492aa886e8bd05ddfb282021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96188-9https://doaj.org/toc/2045-2322Abstract Rats are born deaf and start hearing at the end of the second postnatal week, when the ear canals open and low-intensity sounds start to evoke responses in the auditory cortex. Here, using μECoG electrode arrays and intracortical silicon probe recordings, we found that bone-conducted (BC) sounds evoked biphasic responses in the auditory cortex starting from postnatal day (P) 8. The initial phase of these responses, generated by thalamocortical input, was followed by intracortical propagation within supragranular layers. BC-evoked responses co-localized with the responses evoked by electrical stimulation of the cochlea and the deepest layers of the inferior colliculus prior to onset of low-threshold hearing (P13), as well as with the responses evoked by high-frequency (30 kHz) low-intensity (70 dB) air-conducted sounds after that. Thus, BC signals reach high-frequency processing regions of the auditory cortex well before the onset of low-threshold hearing, reflecting early integrity of the auditory system.Roman MakarovMikhail SintsovGuzel ValeevaPavel StarikovDmitriy NegrovRoustem KhazipovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roman Makarov Mikhail Sintsov Guzel Valeeva Pavel Starikov Dmitriy Negrov Roustem Khazipov Bone conducted responses in the neonatal rat auditory cortex
description	Abstract Rats are born deaf and start hearing at the end of the second postnatal week, when the ear canals open and low-intensity sounds start to evoke responses in the auditory cortex. Here, using μECoG electrode arrays and intracortical silicon probe recordings, we found that bone-conducted (BC) sounds evoked biphasic responses in the auditory cortex starting from postnatal day (P) 8. The initial phase of these responses, generated by thalamocortical input, was followed by intracortical propagation within supragranular layers. BC-evoked responses co-localized with the responses evoked by electrical stimulation of the cochlea and the deepest layers of the inferior colliculus prior to onset of low-threshold hearing (P13), as well as with the responses evoked by high-frequency (30 kHz) low-intensity (70 dB) air-conducted sounds after that. Thus, BC signals reach high-frequency processing regions of the auditory cortex well before the onset of low-threshold hearing, reflecting early integrity of the auditory system.
format	article
author	Roman Makarov Mikhail Sintsov Guzel Valeeva Pavel Starikov Dmitriy Negrov Roustem Khazipov
author_facet	Roman Makarov Mikhail Sintsov Guzel Valeeva Pavel Starikov Dmitriy Negrov Roustem Khazipov
author_sort	Roman Makarov
title	Bone conducted responses in the neonatal rat auditory cortex
title_short	Bone conducted responses in the neonatal rat auditory cortex
title_full	Bone conducted responses in the neonatal rat auditory cortex
title_fullStr	Bone conducted responses in the neonatal rat auditory cortex
title_full_unstemmed	Bone conducted responses in the neonatal rat auditory cortex
title_sort	bone conducted responses in the neonatal rat auditory cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4679469fa4b492aa886e8bd05ddfb28
work_keys_str_mv	AT romanmakarov boneconductedresponsesintheneonatalratauditorycortex AT mikhailsintsov boneconductedresponsesintheneonatalratauditorycortex AT guzelvaleeva boneconductedresponsesintheneonatalratauditorycortex AT pavelstarikov boneconductedresponsesintheneonatalratauditorycortex AT dmitriynegrov boneconductedresponsesintheneonatalratauditorycortex AT roustemkhazipov boneconductedresponsesintheneonatalratauditorycortex
_version_	1718387713980235776

Bone conducted responses in the neonatal rat auditory cortex

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