Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature

Man R ShimDepartment of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAbstract: Ankylosing spondylitis (AS) is a chronic and progressive inflammatory disorder that primarily affects the axial skeleton. Unfortunately, diagnosis of AS i...

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Autor principal:	Shim MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Ankylosing spondylitis advanced tumor necrosis factor inhibitors total spinal fusion. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/b46b1057d65542369cc0e2ddbbcf436a
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spelling	oai:doaj.org-article:b46b1057d65542369cc0e2ddbbcf436a2021-12-02T07:00:11ZEfficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature1179-156Xhttps://doaj.org/article/b46b1057d65542369cc0e2ddbbcf436a2019-07-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-tnf-inhibitors-in-advanced-ankylosing-spondylitis-with-tot-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XMan R ShimDepartment of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAbstract: Ankylosing spondylitis (AS) is a chronic and progressive inflammatory disorder that primarily affects the axial skeleton. Unfortunately, diagnosis of AS is often delayed compared to other rheumatologic conditions. It is not uncommon for patients to already have an advanced disease when the correct diagnosis is eventually made. TNF inhibitors are well-known and effective treatment options in patients with AS. However, many clinical trials have excluded patients with advanced AS. This paper reports a 45-year-old male with newly diagnosed AS with already fused sacroiliac joints, lumbar spine, and cervical spine. Due to persistent and severe pain despite having taken multiple NSAIDs, etanercept was prescribed. After 4 years of treatment, the patient continues to experience marked improvement of his AS symptoms without any significant adverse effects. This case illustrates etanercept can be an effective treatment in patients with advanced AS and is well tolerated. An extensive literature review is also carried out regarding this topic.Keywords: ankylosing spondylitis, advanced, tumor necrosis factor inhibitors, total spinal fusionShim MRDove Medical PressarticleAnkylosing spondylitisadvancedtumor necrosis factor inhibitorstotal spinal fusion.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 11, Pp 173-177 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ankylosing spondylitis advanced tumor necrosis factor inhibitors total spinal fusion. Diseases of the musculoskeletal system RC925-935
spellingShingle	Ankylosing spondylitis advanced tumor necrosis factor inhibitors total spinal fusion. Diseases of the musculoskeletal system RC925-935 Shim MR Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
description	Man R ShimDepartment of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAbstract: Ankylosing spondylitis (AS) is a chronic and progressive inflammatory disorder that primarily affects the axial skeleton. Unfortunately, diagnosis of AS is often delayed compared to other rheumatologic conditions. It is not uncommon for patients to already have an advanced disease when the correct diagnosis is eventually made. TNF inhibitors are well-known and effective treatment options in patients with AS. However, many clinical trials have excluded patients with advanced AS. This paper reports a 45-year-old male with newly diagnosed AS with already fused sacroiliac joints, lumbar spine, and cervical spine. Due to persistent and severe pain despite having taken multiple NSAIDs, etanercept was prescribed. After 4 years of treatment, the patient continues to experience marked improvement of his AS symptoms without any significant adverse effects. This case illustrates etanercept can be an effective treatment in patients with advanced AS and is well tolerated. An extensive literature review is also carried out regarding this topic.Keywords: ankylosing spondylitis, advanced, tumor necrosis factor inhibitors, total spinal fusion
format	article
author	Shim MR
author_facet	Shim MR
author_sort	Shim MR
title	Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
title_short	Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
title_full	Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
title_fullStr	Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
title_full_unstemmed	Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
title_sort	efficacy of tnf inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b46b1057d65542369cc0e2ddbbcf436a
work_keys_str_mv	AT shimmr efficacyoftnfinhibitorsinadvancedankylosingspondylitiswithtotalspinalfusioncasereportandreviewofliterature
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Efficacy of TNF inhibitors in advanced ankylosing spondylitis with total spinal fusion: case report and review of literature

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