α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats

The dorsal raphe (DR) nucleus is involved in a myriad of physiological functions, such as the control of sleep-wake cycle, motivation, pain, energy balance, and food intake. We have previously demonstrated that in ad libitum fed rats the intra-DR administration of phenylephrine, an α-1 receptor agon...

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Autores principales:	Rafael Appel Flores, Raoni Conceição Dos-Santos, Renata Steinbach, Isabelle Rodrigues-Santos, Aline Alves de Jesus, José Antunes-Rodrigues, Marta Aparecida Paschoalini
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dorsal raphe (DR) adrenergic receptor hunger food intake phenylephrine Physiology QP1-981
Acceso en línea:	https://doaj.org/article/b46d9e7a445e4a61be65a0fc6f56fa4a
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spelling	oai:doaj.org-article:b46d9e7a445e4a61be65a0fc6f56fa4a2021-12-01T01:44:46Zα-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats1664-042X10.3389/fphys.2021.775070https://doaj.org/article/b46d9e7a445e4a61be65a0fc6f56fa4a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.775070/fullhttps://doaj.org/toc/1664-042XThe dorsal raphe (DR) nucleus is involved in a myriad of physiological functions, such as the control of sleep-wake cycle, motivation, pain, energy balance, and food intake. We have previously demonstrated that in ad libitum fed rats the intra-DR administration of phenylephrine, an α-1 receptor agonist, does not affect food intake, whereas clonidine, an α-2 receptor agonist, potently stimulates food intake. These results indicated that in fed rats an increased adrenergic tonus blocked food intake, since the activation of α-2 auto-receptors, which decreases pre-synaptic release of adrenaline/noradrenaline, affected food intake. Thus, in this study we assessed whether the response to adrenergic stimuli would differ after overnight fasting, a situation of low adrenergic activity in the DR. Intra-DR administration of adrenaline and noradrenaline blocked food intake evoked by overnight fasting. Similarly, phenylephrine administration decreased hunger-induced food intake. These changes in food intake were accompanied by changes in other behaviors, such as increased immobility time and feeding duration. On the other hand, intra-DR administration of clonidine did not affect food-intake or associated behaviors. These results further support the hypothesis that in fed animals, increased adrenergic tonus in DR neurons inhibiting feeding, while in fasted rats the adrenergic tonus decreases and favors food intake. These data indicate a possible mechanism through which adrenergic input to the DRN contributes to neurobiology of feeding.Rafael Appel FloresRafael Appel FloresRaoni Conceição Dos-SantosRenata SteinbachIsabelle Rodrigues-SantosAline Alves de JesusJosé Antunes-RodriguesMarta Aparecida PaschoaliniFrontiers Media S.A.articledorsal raphe (DR)adrenergic receptorhungerfood intakephenylephrinePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dorsal raphe (DR) adrenergic receptor hunger food intake phenylephrine Physiology QP1-981
spellingShingle	dorsal raphe (DR) adrenergic receptor hunger food intake phenylephrine Physiology QP1-981 Rafael Appel Flores Rafael Appel Flores Raoni Conceição Dos-Santos Renata Steinbach Isabelle Rodrigues-Santos Aline Alves de Jesus José Antunes-Rodrigues Marta Aparecida Paschoalini α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
description	The dorsal raphe (DR) nucleus is involved in a myriad of physiological functions, such as the control of sleep-wake cycle, motivation, pain, energy balance, and food intake. We have previously demonstrated that in ad libitum fed rats the intra-DR administration of phenylephrine, an α-1 receptor agonist, does not affect food intake, whereas clonidine, an α-2 receptor agonist, potently stimulates food intake. These results indicated that in fed rats an increased adrenergic tonus blocked food intake, since the activation of α-2 auto-receptors, which decreases pre-synaptic release of adrenaline/noradrenaline, affected food intake. Thus, in this study we assessed whether the response to adrenergic stimuli would differ after overnight fasting, a situation of low adrenergic activity in the DR. Intra-DR administration of adrenaline and noradrenaline blocked food intake evoked by overnight fasting. Similarly, phenylephrine administration decreased hunger-induced food intake. These changes in food intake were accompanied by changes in other behaviors, such as increased immobility time and feeding duration. On the other hand, intra-DR administration of clonidine did not affect food-intake or associated behaviors. These results further support the hypothesis that in fed animals, increased adrenergic tonus in DR neurons inhibiting feeding, while in fasted rats the adrenergic tonus decreases and favors food intake. These data indicate a possible mechanism through which adrenergic input to the DRN contributes to neurobiology of feeding.
format	article
author	Rafael Appel Flores Rafael Appel Flores Raoni Conceição Dos-Santos Renata Steinbach Isabelle Rodrigues-Santos Aline Alves de Jesus José Antunes-Rodrigues Marta Aparecida Paschoalini
author_facet	Rafael Appel Flores Rafael Appel Flores Raoni Conceição Dos-Santos Renata Steinbach Isabelle Rodrigues-Santos Aline Alves de Jesus José Antunes-Rodrigues Marta Aparecida Paschoalini
author_sort	Rafael Appel Flores
title	α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
title_short	α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
title_full	α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
title_fullStr	α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
title_full_unstemmed	α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats
title_sort	α-1 adrenoceptor activation in the dorsal raphe nucleus decreases food intake in fasted rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b46d9e7a445e4a61be65a0fc6f56fa4a
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α-1 Adrenoceptor Activation in the Dorsal Raphe Nucleus Decreases Food Intake in Fasted Rats

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