Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

NMR structure determination is challenging for proteins with a molecular weight above 30 kDa and atomic-resolution structure determination from cryo-EM data is currently not the rule. Here the authors describe an integrated structure determination approach that simultaneously uses NMR and EM data an...

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Main Authors: Diego F. Gauto, Leandro F. Estrozi, Charles D. Schwieters, Gregory Effantin, Pavel Macek, Remy Sounier, Astrid C. Sivertsen, Elena Schmidt, Rime Kerfah, Guillaume Mas, Jacques-Philippe Colletier, Peter Güntert, Adrien Favier, Guy Schoehn, Paul Schanda, Jerome Boisbouvier
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/b46e113a51c845d98317d17073be2ebe
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https://doaj.org/article/b46e113a51c845d98317d17073be2ebe

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