IL-15 sustains IL-7R-independent ILC2 and ILC3 development

ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.

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Autores principales:	Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan, Marco Colonna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b46e7a90995f4a0ba9254bd9f22911a2
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spelling	oai:doaj.org-article:b46e7a90995f4a0ba9254bd9f22911a22021-12-02T15:39:05ZIL-15 sustains IL-7R-independent ILC2 and ILC3 development10.1038/ncomms146012041-1723https://doaj.org/article/b46e7a90995f4a0ba9254bd9f22911a22017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14601https://doaj.org/toc/2041-1723ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.Michelle L. RobinetteJennifer K. BandoWilbur SongTyler K. UllandSusan GilfillanMarco ColonnaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michelle L. Robinette Jennifer K. Bando Wilbur Song Tyler K. Ulland Susan Gilfillan Marco Colonna IL-15 sustains IL-7R-independent ILC2 and ILC3 development
description	ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.
format	article
author	Michelle L. Robinette Jennifer K. Bando Wilbur Song Tyler K. Ulland Susan Gilfillan Marco Colonna
author_facet	Michelle L. Robinette Jennifer K. Bando Wilbur Song Tyler K. Ulland Susan Gilfillan Marco Colonna
author_sort	Michelle L. Robinette
title	IL-15 sustains IL-7R-independent ILC2 and ILC3 development
title_short	IL-15 sustains IL-7R-independent ILC2 and ILC3 development
title_full	IL-15 sustains IL-7R-independent ILC2 and ILC3 development
title_fullStr	IL-15 sustains IL-7R-independent ILC2 and ILC3 development
title_full_unstemmed	IL-15 sustains IL-7R-independent ILC2 and ILC3 development
title_sort	il-15 sustains il-7r-independent ilc2 and ilc3 development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b46e7a90995f4a0ba9254bd9f22911a2
work_keys_str_mv	AT michellelrobinette il15sustainsil7rindependentilc2andilc3development AT jenniferkbando il15sustainsil7rindependentilc2andilc3development AT wilbursong il15sustainsil7rindependentilc2andilc3development AT tylerkulland il15sustainsil7rindependentilc2andilc3development AT susangilfillan il15sustainsil7rindependentilc2andilc3development AT marcocolonna il15sustainsil7rindependentilc2andilc3development
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IL-15 sustains IL-7R-independent ILC2 and ILC3 development

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