IL-15 sustains IL-7R-independent ILC2 and ILC3 development
ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.
Guardado en:
Autores principales: | Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan, Marco Colonna |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b46e7a90995f4a0ba9254bd9f22911a2 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
por: Korneliusz Golebski, et al.
Publicado: (2019) -
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
por: Ute Bank, et al.
Publicado: (2020) -
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
por: Benyu Liu, et al.
Publicado: (2017) -
Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs
por: Sonika Patial, et al.
Publicado: (2021) -
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
por: Giuseppe Ercolano, et al.
Publicado: (2021)