Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations

Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2...

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Autores principales:	Juba Nait Saada, Georgios Kalantzis, Derek Shyr, Fergus Cooper, Martin Robinson, Alexander Gusev, Pier Francesco Palamara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b46ed8444d8241a18138711153c81b43
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spelling	oai:doaj.org-article:b46ed8444d8241a18138711153c81b432021-12-02T14:40:53ZIdentity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations10.1038/s41467-020-19588-x2041-1723https://doaj.org/article/b46ed8444d8241a18138711153c81b432020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19588-xhttps://doaj.org/toc/2041-1723Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2000 years.Juba Nait SaadaGeorgios KalantzisDerek ShyrFergus CooperMartin RobinsonAlexander GusevPier Francesco PalamaraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juba Nait Saada Georgios Kalantzis Derek Shyr Fergus Cooper Martin Robinson Alexander Gusev Pier Francesco Palamara Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
description	Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2000 years.
format	article
author	Juba Nait Saada Georgios Kalantzis Derek Shyr Fergus Cooper Martin Robinson Alexander Gusev Pier Francesco Palamara
author_facet	Juba Nait Saada Georgios Kalantzis Derek Shyr Fergus Cooper Martin Robinson Alexander Gusev Pier Francesco Palamara
author_sort	Juba Nait Saada
title	Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
title_short	Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
title_full	Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
title_fullStr	Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
title_full_unstemmed	Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
title_sort	identity-by-descent detection across 487,409 british samples reveals fine scale population structure and ultra-rare variant associations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b46ed8444d8241a18138711153c81b43
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Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations

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