Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2...
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Autores principales: | Juba Nait Saada, Georgios Kalantzis, Derek Shyr, Fergus Cooper, Martin Robinson, Alexander Gusev, Pier Francesco Palamara |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Acceso en línea: | https://doaj.org/article/b46ed8444d8241a18138711153c81b43 |
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