Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.

Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order t...

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Autores principales:	Nury N Olaya-Galán, Sandra P Salas-Cárdenas, Jorge L Rodriguez-Sarmiento, Milcíades Ibáñez-Pinilla, Ricardo Monroy, Adriana P Corredor-Figueroa, Wilson Rubiano, Jairo de la Peña, HuaMin Shen, Gertrude C Buehring, Manuel A Patarroyo, Maria F Gutierrez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b471e74620b34cfba709d6d5790fe2ee
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spelling	oai:doaj.org-article:b471e74620b34cfba709d6d5790fe2ee2021-12-02T20:14:27ZRisk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.1932-620310.1371/journal.pone.0257492https://doaj.org/article/b471e74620b34cfba709d6d5790fe2ee2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257492https://doaj.org/toc/1932-6203Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case-control study was conducted among women undergoing breast surgery between 2016-2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088-5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.Nury N Olaya-GalánSandra P Salas-CárdenasJorge L Rodriguez-SarmientoMilcíades Ibáñez-PinillaRicardo MonroyAdriana P Corredor-FigueroaWilson RubianoJairo de la PeñaHuaMin ShenGertrude C BuehringManuel A PatarroyoMaria F GutierrezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257492 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nury N Olaya-Galán Sandra P Salas-Cárdenas Jorge L Rodriguez-Sarmiento Milcíades Ibáñez-Pinilla Ricardo Monroy Adriana P Corredor-Figueroa Wilson Rubiano Jairo de la Peña HuaMin Shen Gertrude C Buehring Manuel A Patarroyo Maria F Gutierrez Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
description	Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case-control study was conducted among women undergoing breast surgery between 2016-2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088-5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.
format	article
author	Nury N Olaya-Galán Sandra P Salas-Cárdenas Jorge L Rodriguez-Sarmiento Milcíades Ibáñez-Pinilla Ricardo Monroy Adriana P Corredor-Figueroa Wilson Rubiano Jairo de la Peña HuaMin Shen Gertrude C Buehring Manuel A Patarroyo Maria F Gutierrez
author_facet	Nury N Olaya-Galán Sandra P Salas-Cárdenas Jorge L Rodriguez-Sarmiento Milcíades Ibáñez-Pinilla Ricardo Monroy Adriana P Corredor-Figueroa Wilson Rubiano Jairo de la Peña HuaMin Shen Gertrude C Buehring Manuel A Patarroyo Maria F Gutierrez
author_sort	Nury N Olaya-Galán
title	Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
title_short	Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
title_full	Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
title_fullStr	Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
title_full_unstemmed	Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.
title_sort	risk factor for breast cancer development under exposure to bovine leukemia virus in colombian women: a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b471e74620b34cfba709d6d5790fe2ee
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Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study.

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