Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes

Abstract Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalis...

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Autores principales:	Tomas I. Gonzales, Kate Westgate, Tessa Strain, Stefanie Hollidge, Justin Jeon, Dirk L. Christensen, Jorgen Jensen, Nicholas J. Wareham, Søren Brage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b475b82e64d449d286c7171ffa75b919
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spelling	oai:doaj.org-article:b475b82e64d449d286c7171ffa75b9192021-12-02T16:06:43ZCardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes10.1038/s41598-021-94768-32045-2322https://doaj.org/article/b475b82e64d449d286c7171ffa75b9192021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94768-3https://doaj.org/toc/2045-2322Abstract Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalised exercise tests. We apply the method to examine associations between CRF and health outcomes in the UK Biobank study, one of the world’s largest and most inclusive studies of CRF, showing that risk of all-cause mortality is 8% lower (95%CI 5–11%, 2670 deaths among 79,981 participants) and cardiovascular mortality is 9% lower (95%CI 4–14%, 854 deaths) per 1-metabolic equivalent difference in CRF. Associations obtained with the novel validated CRF estimation method are stronger than those obtained using previous methodology, suggesting previous methods may have underestimated the importance of fitness for human health.Tomas I. GonzalesKate WestgateTessa StrainStefanie HollidgeJustin JeonDirk L. ChristensenJorgen JensenNicholas J. WarehamSøren BrageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomas I. Gonzales Kate Westgate Tessa Strain Stefanie Hollidge Justin Jeon Dirk L. Christensen Jorgen Jensen Nicholas J. Wareham Søren Brage Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
description	Abstract Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalised exercise tests. We apply the method to examine associations between CRF and health outcomes in the UK Biobank study, one of the world’s largest and most inclusive studies of CRF, showing that risk of all-cause mortality is 8% lower (95%CI 5–11%, 2670 deaths among 79,981 participants) and cardiovascular mortality is 9% lower (95%CI 4–14%, 854 deaths) per 1-metabolic equivalent difference in CRF. Associations obtained with the novel validated CRF estimation method are stronger than those obtained using previous methodology, suggesting previous methods may have underestimated the importance of fitness for human health.
format	article
author	Tomas I. Gonzales Kate Westgate Tessa Strain Stefanie Hollidge Justin Jeon Dirk L. Christensen Jorgen Jensen Nicholas J. Wareham Søren Brage
author_facet	Tomas I. Gonzales Kate Westgate Tessa Strain Stefanie Hollidge Justin Jeon Dirk L. Christensen Jorgen Jensen Nicholas J. Wareham Søren Brage
author_sort	Tomas I. Gonzales
title	Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
title_short	Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
title_full	Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
title_fullStr	Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
title_full_unstemmed	Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
title_sort	cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b475b82e64d449d286c7171ffa75b919
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Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes

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