Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene ex...

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Autores principales:	Zaur M. Kachaev, Sergey D. Ivashchenko, Eugene N. Kozlov, Lyubov A. Lebedeva, Yulii V. Shidlovskii
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	translation factor ribosomal protein gene expression nucleus stress cell response Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b4767ed2378747278648884b1458ecba
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spelling	oai:doaj.org-article:b4767ed2378747278648884b1458ecba2021-11-25T17:13:11ZLocalization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus10.3390/cells101132392073-4409https://doaj.org/article/b4767ed2378747278648884b1458ecba2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3239https://doaj.org/toc/2073-4409Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus.Zaur M. KachaevSergey D. IvashchenkoEugene N. KozlovLyubov A. LebedevaYulii V. ShidlovskiiMDPI AGarticletranslation factorribosomal proteingene expressionnucleusstresscell responseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3239, p 3239 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	translation factor ribosomal protein gene expression nucleus stress cell response Biology (General) QH301-705.5
spellingShingle	translation factor ribosomal protein gene expression nucleus stress cell response Biology (General) QH301-705.5 Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
description	Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus.
format	article
author	Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii
author_facet	Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii
author_sort	Zaur M. Kachaev
title	Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_short	Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_full	Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_fullStr	Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_full_unstemmed	Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_sort	localization and functional roles of components of the translation apparatus in the eukaryotic cell nucleus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b4767ed2378747278648884b1458ecba
work_keys_str_mv	AT zaurmkachaev localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT sergeydivashchenko localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT eugenenkozlov localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT lyubovalebedeva localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT yuliivshidlovskii localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus
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Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

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