Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Eun Ran Kim, Yuanzhong Xu, Ryan M. Cassidy, Yungang Lu, Yongjie Yang, Jinbin Tian, De-Pei Li, Rachel Van Drunen, Aleix Ribas-Latre, Zhao-Lin Cai, Mingshan Xue, Benjamin R. Arenkiel, Kristin Eckel-Mahan, Yong Xu, Qingchun Tong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b479012e40434818870fa48db8ae759a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b479012e40434818870fa48db8ae759a
record_format	dspace
spelling	oai:doaj.org-article:b479012e40434818870fa48db8ae759a2021-12-02T16:23:44ZParaventricular hypothalamus mediates diurnal rhythm of metabolism10.1038/s41467-020-17578-72041-1723https://doaj.org/article/b479012e40434818870fa48db8ae759a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17578-7https://doaj.org/toc/2041-1723Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.Eun Ran KimYuanzhong XuRyan M. CassidyYungang LuYongjie YangJinbin TianDe-Pei LiRachel Van DrunenAleix Ribas-LatreZhao-Lin CaiMingshan XueBenjamin R. ArenkielKristin Eckel-MahanYong XuQingchun TongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eun Ran Kim Yuanzhong Xu Ryan M. Cassidy Yungang Lu Yongjie Yang Jinbin Tian De-Pei Li Rachel Van Drunen Aleix Ribas-Latre Zhao-Lin Cai Mingshan Xue Benjamin R. Arenkiel Kristin Eckel-Mahan Yong Xu Qingchun Tong Paraventricular hypothalamus mediates diurnal rhythm of metabolism
description	Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.
format	article
author	Eun Ran Kim Yuanzhong Xu Ryan M. Cassidy Yungang Lu Yongjie Yang Jinbin Tian De-Pei Li Rachel Van Drunen Aleix Ribas-Latre Zhao-Lin Cai Mingshan Xue Benjamin R. Arenkiel Kristin Eckel-Mahan Yong Xu Qingchun Tong
author_facet	Eun Ran Kim Yuanzhong Xu Ryan M. Cassidy Yungang Lu Yongjie Yang Jinbin Tian De-Pei Li Rachel Van Drunen Aleix Ribas-Latre Zhao-Lin Cai Mingshan Xue Benjamin R. Arenkiel Kristin Eckel-Mahan Yong Xu Qingchun Tong
author_sort	Eun Ran Kim
title	Paraventricular hypothalamus mediates diurnal rhythm of metabolism
title_short	Paraventricular hypothalamus mediates diurnal rhythm of metabolism
title_full	Paraventricular hypothalamus mediates diurnal rhythm of metabolism
title_fullStr	Paraventricular hypothalamus mediates diurnal rhythm of metabolism
title_full_unstemmed	Paraventricular hypothalamus mediates diurnal rhythm of metabolism
title_sort	paraventricular hypothalamus mediates diurnal rhythm of metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b479012e40434818870fa48db8ae759a
work_keys_str_mv	AT eunrankim paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT yuanzhongxu paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT ryanmcassidy paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT yunganglu paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT yongjieyang paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT jinbintian paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT depeili paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT rachelvandrunen paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT aleixribaslatre paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT zhaolincai paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT mingshanxue paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT benjaminrarenkiel paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT kristineckelmahan paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT yongxu paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism AT qingchuntong paraventricularhypothalamusmediatesdiurnalrhythmofmetabolism
_version_	1718384131760455680

Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Ejemplares similares