Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.

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Autores principales: Eun Ran Kim, Yuanzhong Xu, Ryan M. Cassidy, Yungang Lu, Yongjie Yang, Jinbin Tian, De-Pei Li, Rachel Van Drunen, Aleix Ribas-Latre, Zhao-Lin Cai, Mingshan Xue, Benjamin R. Arenkiel, Kristin Eckel-Mahan, Yong Xu, Qingchun Tong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/b479012e40434818870fa48db8ae759a
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https://doaj.org/article/b479012e40434818870fa48db8ae759a

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