Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis

Interleukin (IL)-8 has been shown to play an important role in obstructive sleep apnea syndrome (OSAS). However, its role in OSAS development is still controversial. This meta-analysis was to explore the correlation between interleukin (IL)-8concentration and OSAS. Database (from the inception to Ju...

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Autores principales:	Xiaoyan Li, Rong Hu, Xinyi Ren, Jie He
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	obstructive sleep apnea syndrome interleukin-8 serum plasma meta-analysis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/b47ec2b08bc54506bfddc9f60fab0ca0
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spelling	oai:doaj.org-article:b47ec2b08bc54506bfddc9f60fab0ca02021-11-11T14:23:43ZInterleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis2165-59792165-598710.1080/21655979.2021.2001203https://doaj.org/article/b47ec2b08bc54506bfddc9f60fab0ca02021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2001203https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Interleukin (IL)-8 has been shown to play an important role in obstructive sleep apnea syndrome (OSAS). However, its role in OSAS development is still controversial. This meta-analysis was to explore the correlation between interleukin (IL)-8concentration and OSAS. Database (from the inception to July 2021) searches on PubMed, Web of Science, Medline, EMBASE, and Cochrane Library were conducted for studies analyzing the correlation between IL-8 concentration and OSAS, regardless of the language of publication. Standardized mean difference (SMD) and 95% confidence intervals (CI) were used to analyze any prospective association between IL-8 concentration and OSAS.A total of 25 eligible studies, including 2301 participants and 1123 controls, were included in this meta-analysis. The included studies evaluating the association between serum IL-8 concentration and OSAS indicated that adults and children with OSAS had elevated serum concentrations of IL-8 compared with controls (SMD = 0.997, 95% CI = 0.437-1.517, P<0.001; SMD = 0.431, 95% CI = 0.104-0.759, P = 0.01). Categorization of the study population into subgroups according to body mass index, apnea-hypopnea index (AHI), ethnicity, and sample size also showed that individuals with OSAS had elevated serum concentrations of IL-8 compared with controls. Additionally, the results demonstrated that higher the AHI, higher was the IL-8 concentration. Similar results were observed in the literature on the association between plasma IL-8 concentration and OSAS. This meta-analysis verified that compared with controls, children and adults with OSAS have significantly elevated IL-8 concentrations.Xiaoyan LiRong HuXinyi RenJie HeTaylor & Francis Grouparticleobstructive sleep apnea syndromeinterleukin-8serumplasmameta-analysisBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea syndrome interleukin-8 serum plasma meta-analysis Biotechnology TP248.13-248.65
spellingShingle	obstructive sleep apnea syndrome interleukin-8 serum plasma meta-analysis Biotechnology TP248.13-248.65 Xiaoyan Li Rong Hu Xinyi Ren Jie He Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
description	Interleukin (IL)-8 has been shown to play an important role in obstructive sleep apnea syndrome (OSAS). However, its role in OSAS development is still controversial. This meta-analysis was to explore the correlation between interleukin (IL)-8concentration and OSAS. Database (from the inception to July 2021) searches on PubMed, Web of Science, Medline, EMBASE, and Cochrane Library were conducted for studies analyzing the correlation between IL-8 concentration and OSAS, regardless of the language of publication. Standardized mean difference (SMD) and 95% confidence intervals (CI) were used to analyze any prospective association between IL-8 concentration and OSAS.A total of 25 eligible studies, including 2301 participants and 1123 controls, were included in this meta-analysis. The included studies evaluating the association between serum IL-8 concentration and OSAS indicated that adults and children with OSAS had elevated serum concentrations of IL-8 compared with controls (SMD = 0.997, 95% CI = 0.437-1.517, P<0.001; SMD = 0.431, 95% CI = 0.104-0.759, P = 0.01). Categorization of the study population into subgroups according to body mass index, apnea-hypopnea index (AHI), ethnicity, and sample size also showed that individuals with OSAS had elevated serum concentrations of IL-8 compared with controls. Additionally, the results demonstrated that higher the AHI, higher was the IL-8 concentration. Similar results were observed in the literature on the association between plasma IL-8 concentration and OSAS. This meta-analysis verified that compared with controls, children and adults with OSAS have significantly elevated IL-8 concentrations.
format	article
author	Xiaoyan Li Rong Hu Xinyi Ren Jie He
author_facet	Xiaoyan Li Rong Hu Xinyi Ren Jie He
author_sort	Xiaoyan Li
title	Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
title_short	Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
title_full	Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
title_fullStr	Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
title_full_unstemmed	Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis
title_sort	interleukin-8 concentrations in obstructive sleep apnea syndrome: a systematic review and meta-analysis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/b47ec2b08bc54506bfddc9f60fab0ca0
work_keys_str_mv	AT xiaoyanli interleukin8concentrationsinobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT ronghu interleukin8concentrationsinobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT xinyiren interleukin8concentrationsinobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT jiehe interleukin8concentrationsinobstructivesleepapneasyndromeasystematicreviewandmetaanalysis
_version_	1718438977552252928

Interleukin-8 concentrations in obstructive sleep apnea syndrome: A systematic review and meta-analysis

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