The Emerging Role of Non-Coding RNAs in Osteoarthritis

Osteoarthritis (OS) is the most frequent degenerative condition in the joints, disabling many adults. Several abnormalities in the articular cartilage, subchondral bone, synovial tissue, and meniscus have been detected in the course of OA. Destruction of articular cartilage, the formation of osteoph...

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Autores principales:	Soudeh Ghafouri-Fard, Christophe Poulet, Michel Malaise, Atefe Abak, Bashdar Mahmud Hussen, Afshin Taheriazam, Mohammad Taheri, Mohammad Hallajnejad
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNA miRNA osteoarthritis ncRNAs expression circRNA Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b47ede56381b4b318871cf8ae244b17b
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spelling	oai:doaj.org-article:b47ede56381b4b318871cf8ae244b17b2021-12-01T11:31:28ZThe Emerging Role of Non-Coding RNAs in Osteoarthritis1664-322410.3389/fimmu.2021.773171https://doaj.org/article/b47ede56381b4b318871cf8ae244b17b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.773171/fullhttps://doaj.org/toc/1664-3224Osteoarthritis (OS) is the most frequent degenerative condition in the joints, disabling many adults. Several abnormalities in the articular cartilage, subchondral bone, synovial tissue, and meniscus have been detected in the course of OA. Destruction of articular cartilage, the formation of osteophytes, subchondral sclerosis, and hyperplasia of synovial tissue are hallmarks of OA. More recently, several investigations have underscored the regulatory roles of non-coding RNAs (ncRNAs) in OA development. Different classes of non-coding RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), have been reported to affect the development of OA. The expression level of these transcripts has also been used as diagnostic tools in OA. In the present article, we aimed at reporting the role of these transcripts in this process. We need to give a specific angle on the pathology to provide meaningful thoughts on it.Soudeh Ghafouri-FardChristophe PouletChristophe PouletChristophe PouletMichel MalaiseMichel MalaiseMichel MalaiseAtefe AbakBashdar Mahmud HussenBashdar Mahmud HussenAfshin TaheriazamMohammad TaheriMohammad HallajnejadFrontiers Media S.A.articlelncRNAmiRNAosteoarthritisncRNAsexpressioncircRNAImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNA miRNA osteoarthritis ncRNAs expression circRNA Immunologic diseases. Allergy RC581-607
spellingShingle	lncRNA miRNA osteoarthritis ncRNAs expression circRNA Immunologic diseases. Allergy RC581-607 Soudeh Ghafouri-Fard Christophe Poulet Christophe Poulet Christophe Poulet Michel Malaise Michel Malaise Michel Malaise Atefe Abak Bashdar Mahmud Hussen Bashdar Mahmud Hussen Afshin Taheriazam Mohammad Taheri Mohammad Hallajnejad The Emerging Role of Non-Coding RNAs in Osteoarthritis
description	Osteoarthritis (OS) is the most frequent degenerative condition in the joints, disabling many adults. Several abnormalities in the articular cartilage, subchondral bone, synovial tissue, and meniscus have been detected in the course of OA. Destruction of articular cartilage, the formation of osteophytes, subchondral sclerosis, and hyperplasia of synovial tissue are hallmarks of OA. More recently, several investigations have underscored the regulatory roles of non-coding RNAs (ncRNAs) in OA development. Different classes of non-coding RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), have been reported to affect the development of OA. The expression level of these transcripts has also been used as diagnostic tools in OA. In the present article, we aimed at reporting the role of these transcripts in this process. We need to give a specific angle on the pathology to provide meaningful thoughts on it.
format	article
author	Soudeh Ghafouri-Fard Christophe Poulet Christophe Poulet Christophe Poulet Michel Malaise Michel Malaise Michel Malaise Atefe Abak Bashdar Mahmud Hussen Bashdar Mahmud Hussen Afshin Taheriazam Mohammad Taheri Mohammad Hallajnejad
author_facet	Soudeh Ghafouri-Fard Christophe Poulet Christophe Poulet Christophe Poulet Michel Malaise Michel Malaise Michel Malaise Atefe Abak Bashdar Mahmud Hussen Bashdar Mahmud Hussen Afshin Taheriazam Mohammad Taheri Mohammad Hallajnejad
author_sort	Soudeh Ghafouri-Fard
title	The Emerging Role of Non-Coding RNAs in Osteoarthritis
title_short	The Emerging Role of Non-Coding RNAs in Osteoarthritis
title_full	The Emerging Role of Non-Coding RNAs in Osteoarthritis
title_fullStr	The Emerging Role of Non-Coding RNAs in Osteoarthritis
title_full_unstemmed	The Emerging Role of Non-Coding RNAs in Osteoarthritis
title_sort	emerging role of non-coding rnas in osteoarthritis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b47ede56381b4b318871cf8ae244b17b
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The Emerging Role of Non-Coding RNAs in Osteoarthritis

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