Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering

Plants employ a diversified array of defense activities when they encounter stress. Continuous activation of defense pathways that were induced by mutation or altered expression of disease resistance genes and mRNA surveillance mechanisms develop abnormal phenotypes. These plants show continuous def...

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Autores principales:	Lakshmipriya Perincherry, Łukasz Stępień, Soniya Eppurathu Vasudevan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autoimmunity stress tolerance metabolic engineering Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b480d1cc14614803b0d8e9cd9d956df4
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spelling	oai:doaj.org-article:b480d1cc14614803b0d8e9cd9d956df42021-11-11T17:21:44ZCross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering10.3390/ijms2221119451422-00671661-6596https://doaj.org/article/b480d1cc14614803b0d8e9cd9d956df42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11945https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Plants employ a diversified array of defense activities when they encounter stress. Continuous activation of defense pathways that were induced by mutation or altered expression of disease resistance genes and mRNA surveillance mechanisms develop abnormal phenotypes. These plants show continuous defense genes’ expression, reduced growth, and also manifest tissue damage by apoptosis. These macroscopic abrasions appear even in the absence of the pathogen and can be attributed to a condition known as autoimmunity. The question is whether it is possible to develop an autoimmune mutant that does not fetch yield and growth penalty and provides enhanced protection against various biotic and abiotic stresses via secondary metabolic pathways’ engineering. This review is a discussion about the common stress-fighting mechanisms, how the concept of cross-tolerance instigates propitious or protective autoimmunity, and how it can be achieved by engineering secondary metabolic pathways.Lakshmipriya PerincherryŁukasz StępieńSoniya Eppurathu VasudevanMDPI AGarticleautoimmunitystress tolerancemetabolic engineeringBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11945, p 11945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmunity stress tolerance metabolic engineering Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	autoimmunity stress tolerance metabolic engineering Biology (General) QH301-705.5 Chemistry QD1-999 Lakshmipriya Perincherry Łukasz Stępień Soniya Eppurathu Vasudevan Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
description	Plants employ a diversified array of defense activities when they encounter stress. Continuous activation of defense pathways that were induced by mutation or altered expression of disease resistance genes and mRNA surveillance mechanisms develop abnormal phenotypes. These plants show continuous defense genes’ expression, reduced growth, and also manifest tissue damage by apoptosis. These macroscopic abrasions appear even in the absence of the pathogen and can be attributed to a condition known as autoimmunity. The question is whether it is possible to develop an autoimmune mutant that does not fetch yield and growth penalty and provides enhanced protection against various biotic and abiotic stresses via secondary metabolic pathways’ engineering. This review is a discussion about the common stress-fighting mechanisms, how the concept of cross-tolerance instigates propitious or protective autoimmunity, and how it can be achieved by engineering secondary metabolic pathways.
format	article
author	Lakshmipriya Perincherry Łukasz Stępień Soniya Eppurathu Vasudevan
author_facet	Lakshmipriya Perincherry Łukasz Stępień Soniya Eppurathu Vasudevan
author_sort	Lakshmipriya Perincherry
title	Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
title_short	Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
title_full	Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
title_fullStr	Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
title_full_unstemmed	Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering
title_sort	cross-tolerance and autoimmunity as missing links in abiotic and biotic stress responses in plants: a perspective toward secondary metabolic engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b480d1cc14614803b0d8e9cd9d956df4
work_keys_str_mv	AT lakshmipriyaperincherry crosstoleranceandautoimmunityasmissinglinksinabioticandbioticstressresponsesinplantsaperspectivetowardsecondarymetabolicengineering AT łukaszstepien crosstoleranceandautoimmunityasmissinglinksinabioticandbioticstressresponsesinplantsaperspectivetowardsecondarymetabolicengineering AT soniyaeppurathuvasudevan crosstoleranceandautoimmunityasmissinglinksinabioticandbioticstressresponsesinplantsaperspectivetowardsecondarymetabolicengineering
_version_	1718432140058689536

Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering

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