The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients

At the present time virtually no data are available about the structure of the genus Candida fungus able to target HIV-infected patients and serve as an etiological factor of candidiasis. The aforementioned shaped the aim of the study: to examine structure of the Candida genus community colonizing t...

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Autores principales:	A. D. Voropaev, D. A. Yekaterinchev, Yu. V. Nesvizhsky, V. V. Zverev, S. S. Afanasiev, E. V. Volchkova, M. S. Afanasiev, E. V. Budanova, R. E. Boshjan, E. I. Likhanskaya, Y. N. Urban, Yu. S. Filina, M. E. Suleymanova, V. A. Voropaeva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	fungi of the genus candida structure of the microbial community architectonics of the microbial community hiv-infected patients oropharyngeal candidiasis antimycotic resistance Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/b48222ba4f9e4f779111d29097067e5a
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spelling	oai:doaj.org-article:b48222ba4f9e4f779111d29097067e5a2021-11-22T07:09:55ZThe structure of the oropharyngeal genus Candida fungi community in HIVinfected patients2220-76192313-739810.15789/2220-7619-TSO-1450https://doaj.org/article/b48222ba4f9e4f779111d29097067e5a2021-09-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1450https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398At the present time virtually no data are available about the structure of the genus Candida fungus able to target HIV-infected patients and serve as an etiological factor of candidiasis. The aforementioned shaped the aim of the study: to examine structure of the Candida genus community colonizing the oropharynx in HIV-infected patients with clinical manifestations of oropharyngeal candidiasis. There was conducted a microbiological study of the oropharynx in 31 HIV-infected patients (51.6% males and 48.4% females) with clinical manifestations of oropharyngeal candidiasis treated at Moscow Infectious Clinic No. 2 inpatient department in the years 2015–2017. We confirmed the diversity of the oropharyngeal Candida spp. community found in HIV-infected patients. Total 52 isolates of the genus Candida were isolated. C. albicans dominated in 57.7% cases, whereas C. glabrata prevailed (21.1%) among non-albicans species. Minor components were represented by C. tropicalis (11.5%) and C. krusei (9.6%). C. albicans and C. glabrata were sensitive to polyenes, whereas minor community components — to itroconazole and clotrimazole. The vast majority of fungal strains were resistant to fluconazole. The genus Candida community reveals a unique architecture so that any member may exist in the oropharyngeal biotope of HIV-infected patients as a monoculture or in association: homogeneous, consisting of a single species strains, or heterogeneous, formed by several species. Candida fungi in 18 patients (58.1%) were isolated as a monoculture, whereas in 13 (41.9%) subjects — in association consisting of 34 isolates (65.4% of total number), of which 16 (30.8%) and 18 (34.6%) were isolated from homogeneous and heterogeneous associations, respectively. There were identified 9 two-component associations (69.2%), and 4 (30.8%) consisting of three or more components. It turned out that pattern of the examined community was mainly determined by species composition that agrees with previous data. Most common associations were presented by C. krusei (100%) and C. albicans (73.3%). Upon that, most often C. albicans (72.7%) formed a homogeneous type of associations. Sensitivity of Candida fungi to antimycotic drugs also depended on the architecture of related community. C. albicans isolates in heterogeneous associations revealed a wide range of resistance acquired by contact with non-albicans species.A. D. VoropaevD. A. YekaterinchevYu. V. NesvizhskyV. V. ZverevS. S. AfanasievE. V. VolchkovaM. S. AfanasievE. V. BudanovaR. E. BoshjanE. I. LikhanskayaY. N. UrbanYu. S. FilinaM. E. SuleymanovaV. A. VoropaevaSankt-Peterburg : NIIÈM imeni Pasteraarticlefungi of the genus candidastructure of the microbial communityarchitectonics of the microbial communityhiv-infected patientsoropharyngeal candidiasisantimycotic resistanceInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 4, Pp 737-745 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	fungi of the genus candida structure of the microbial community architectonics of the microbial community hiv-infected patients oropharyngeal candidiasis antimycotic resistance Infectious and parasitic diseases RC109-216
spellingShingle	fungi of the genus candida structure of the microbial community architectonics of the microbial community hiv-infected patients oropharyngeal candidiasis antimycotic resistance Infectious and parasitic diseases RC109-216 A. D. Voropaev D. A. Yekaterinchev Yu. V. Nesvizhsky V. V. Zverev S. S. Afanasiev E. V. Volchkova M. S. Afanasiev E. V. Budanova R. E. Boshjan E. I. Likhanskaya Y. N. Urban Yu. S. Filina M. E. Suleymanova V. A. Voropaeva The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
description	At the present time virtually no data are available about the structure of the genus Candida fungus able to target HIV-infected patients and serve as an etiological factor of candidiasis. The aforementioned shaped the aim of the study: to examine structure of the Candida genus community colonizing the oropharynx in HIV-infected patients with clinical manifestations of oropharyngeal candidiasis. There was conducted a microbiological study of the oropharynx in 31 HIV-infected patients (51.6% males and 48.4% females) with clinical manifestations of oropharyngeal candidiasis treated at Moscow Infectious Clinic No. 2 inpatient department in the years 2015–2017. We confirmed the diversity of the oropharyngeal Candida spp. community found in HIV-infected patients. Total 52 isolates of the genus Candida were isolated. C. albicans dominated in 57.7% cases, whereas C. glabrata prevailed (21.1%) among non-albicans species. Minor components were represented by C. tropicalis (11.5%) and C. krusei (9.6%). C. albicans and C. glabrata were sensitive to polyenes, whereas minor community components — to itroconazole and clotrimazole. The vast majority of fungal strains were resistant to fluconazole. The genus Candida community reveals a unique architecture so that any member may exist in the oropharyngeal biotope of HIV-infected patients as a monoculture or in association: homogeneous, consisting of a single species strains, or heterogeneous, formed by several species. Candida fungi in 18 patients (58.1%) were isolated as a monoculture, whereas in 13 (41.9%) subjects — in association consisting of 34 isolates (65.4% of total number), of which 16 (30.8%) and 18 (34.6%) were isolated from homogeneous and heterogeneous associations, respectively. There were identified 9 two-component associations (69.2%), and 4 (30.8%) consisting of three or more components. It turned out that pattern of the examined community was mainly determined by species composition that agrees with previous data. Most common associations were presented by C. krusei (100%) and C. albicans (73.3%). Upon that, most often C. albicans (72.7%) formed a homogeneous type of associations. Sensitivity of Candida fungi to antimycotic drugs also depended on the architecture of related community. C. albicans isolates in heterogeneous associations revealed a wide range of resistance acquired by contact with non-albicans species.
format	article
author	A. D. Voropaev D. A. Yekaterinchev Yu. V. Nesvizhsky V. V. Zverev S. S. Afanasiev E. V. Volchkova M. S. Afanasiev E. V. Budanova R. E. Boshjan E. I. Likhanskaya Y. N. Urban Yu. S. Filina M. E. Suleymanova V. A. Voropaeva
author_facet	A. D. Voropaev D. A. Yekaterinchev Yu. V. Nesvizhsky V. V. Zverev S. S. Afanasiev E. V. Volchkova M. S. Afanasiev E. V. Budanova R. E. Boshjan E. I. Likhanskaya Y. N. Urban Yu. S. Filina M. E. Suleymanova V. A. Voropaeva
author_sort	A. D. Voropaev
title	The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
title_short	The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
title_full	The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
title_fullStr	The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
title_full_unstemmed	The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients
title_sort	structure of the oropharyngeal genus candida fungi community in hivinfected patients
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/b48222ba4f9e4f779111d29097067e5a
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The structure of the oropharyngeal genus Candida fungi community in HIVinfected patients

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