Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder
Abstract Exposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR. We carried out a meta-analysis of studies investigating the interaction between 5-HTTLPR, stress, and PTSD to clarify the interrel...
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Nature Portfolio
2017
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oai:doaj.org-article:b48242106688435494e19a24a4ea76cb2021-12-02T15:06:10ZMeta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder10.1038/s41598-017-15168-02045-2322https://doaj.org/article/b48242106688435494e19a24a4ea76cb2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15168-0https://doaj.org/toc/2045-2322Abstract Exposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR. We carried out a meta-analysis of studies investigating the interaction between 5-HTTLPR, stress, and PTSD to clarify the interrelatedness of these factors. We reviewed all relevant studies published in English before May 2016. The Lipták–Stouffer z-score method for meta-analysis was applied to combined data. The z score was separately calculated for the stressful life events, childhood adversity, bi- and triallelic loci, and cross-sectional and longitudinal studies subgroups. A total of 14 studies with 15,883 subjects met our inclusion criteria. We found strong evidence that the presence of 5-HTTLPR influenced the relationship between stress and PTSD (P = 0.00003), with the strongest effects observed in the cross-sectional and longitudinal groups (P = 0.01 and 2.0 × 10−6, respectively). Stressful life events and childhood adversity separately interacted with 5-HTTLPR in PTSD (P = 2.0 × 10−8 and 0.003, respectively). When the studies were stratified by locus classification, the evidence was stronger for the triallelic (P = 4.0 × 10−8) than for the biallelic (P = 0.054) locus subgroup. There was strong evidence that 5-HTTLPR influences the relationship between stress and PTSD.Mingzhe ZhaoJiarun YangWenbo WangJingsong MaJian ZhangXueyan ZhaoXiaohui QiuXiuxian YangZhengxue QiaoXuejia SongLin WangShixiang JiangErying ZhaoYanjie YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q Mingzhe Zhao Jiarun Yang Wenbo Wang Jingsong Ma Jian Zhang Xueyan Zhao Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Shixiang Jiang Erying Zhao Yanjie Yang Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| description |
Abstract Exposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR. We carried out a meta-analysis of studies investigating the interaction between 5-HTTLPR, stress, and PTSD to clarify the interrelatedness of these factors. We reviewed all relevant studies published in English before May 2016. The Lipták–Stouffer z-score method for meta-analysis was applied to combined data. The z score was separately calculated for the stressful life events, childhood adversity, bi- and triallelic loci, and cross-sectional and longitudinal studies subgroups. A total of 14 studies with 15,883 subjects met our inclusion criteria. We found strong evidence that the presence of 5-HTTLPR influenced the relationship between stress and PTSD (P = 0.00003), with the strongest effects observed in the cross-sectional and longitudinal groups (P = 0.01 and 2.0 × 10−6, respectively). Stressful life events and childhood adversity separately interacted with 5-HTTLPR in PTSD (P = 2.0 × 10−8 and 0.003, respectively). When the studies were stratified by locus classification, the evidence was stronger for the triallelic (P = 4.0 × 10−8) than for the biallelic (P = 0.054) locus subgroup. There was strong evidence that 5-HTTLPR influences the relationship between stress and PTSD. |
| format |
article |
| author |
Mingzhe Zhao Jiarun Yang Wenbo Wang Jingsong Ma Jian Zhang Xueyan Zhao Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Shixiang Jiang Erying Zhao Yanjie Yang |
| author_facet |
Mingzhe Zhao Jiarun Yang Wenbo Wang Jingsong Ma Jian Zhang Xueyan Zhao Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Shixiang Jiang Erying Zhao Yanjie Yang |
| author_sort |
Mingzhe Zhao |
| title |
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| title_short |
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| title_full |
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| title_fullStr |
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| title_full_unstemmed |
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| title_sort |
meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/b48242106688435494e19a24a4ea76cb |
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