Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization

Gianfranco Piccirillo,1 Federica Moscucci,1 Matteo Pascucci,1 Maria Antonella Pappadà,1 Gaetana D’Alessandro,1 Pietro Rossi,2 Raffaele Quaglione,1 Daniele Di Barba,1 Francesco Barillà,1 Damiano Magrì3 1Department of Cardiovascular, Respiratory, Nephrologica...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Piccirillo G, Moscucci F, Pascucci M, Pappadà MA, D’Alessandro G, Rossi P, Quaglione R, Di Barba D, Barillà F, Magrì D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Cardiac repolarization QT variability index QT dynamic sudden cardiac death ventricular arrhythmias chronic heart failure aging Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b484901092594e50b430326eb64f61e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b484901092594e50b430326eb64f61e1
record_format	dspace
spelling	oai:doaj.org-article:b484901092594e50b430326eb64f61e12021-12-02T05:52:39ZInfluence of aging and chronic heart failure on temporal dispersion of myocardial repolarization1178-1998https://doaj.org/article/b484901092594e50b430326eb64f61e12013-03-01T00:00:00Zhttps://www.dovepress.com/influence-of-aging-and-chronic-heart-failure-on-temporal-dispersion-of-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Gianfranco Piccirillo,1 Federica Moscucci,1 Matteo Pascucci,1 Maria Antonella Pappadà,1 Gaetana D’Alessandro,1 Pietro Rossi,2 Raffaele Quaglione,1 Daniele Di Barba,1 Francesco Barillà,1 Damiano Magrì3 1Department of Cardiovascular, Respiratory, Nephrological and Geriatric Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy; 2Division of Cardiology, S. Giovanni Calabita Fatebenefratelli Hospital, Rome, Italy; 3Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, “Sapienza” University of Rome, Rome, Italy Background and purpose: QT and Tpeak-Tend (Te) intervals are associated with sudden cardiac death in patients with chronic heart failure (CHF). We studied age-dependent influence on short-term temporal dispersion of these two variables in patients with postischemic CHF. Method: We grouped 75 CHF and 53 healthy control subjects into three age subsets: ≤50 years, >50 years and ≤65 years, and >65 years. We then calculated the following indices: QT and Te variability index (QTVI and TeVI), the ratio between the short-term variability (STV) of QT or Te, and the STV of resting rate (RR) (QT/RR STV and Te/RR STV). Results: In all different age subgroups, patients with CHF showed a higher level of QTVI than age-matched control subjects (≤50 years: P < 0.0001; >50 years and ≤65 years: P < 0.05; >65 years: P <  0.05). Patients with CHF < 50 years old also had all repolarization variability indices higher than normal age-matched controls (TeVI, P < 0.05; QT/RR STV, P < 0.05; Te/RR STV, P < 0.05), whereas we did not find any difference between the two older classes of subjects. Both QTVI (r2: 0.178, P < 0.05) and TeVI (r2: 0.433, P < 0.001) were positively related to age in normal subjects, even if the first correlation was weaker than the second one. Conclusion: Our data showed that QTVI could be used in all ages to evaluate repolarization temporal liability, whereas the other indices are deeply influenced by age. Probably, the age-dependent increase in QTVI was more influenced by a reduction of RR variability reported in older normal subjects. Keywords: aging, QT variability, heart rate variability, chronic heart failure, sudden deathPiccirillo GMoscucci FPascucci MPappadà MAD’Alessandro GRossi PQuaglione RDi Barba DBarillà FMagrì DDove Medical PressarticleCardiac repolarizationQT variability indexQT dynamicsudden cardiac deathventricular arrhythmiaschronic heart failureagingGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 293-300 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiac repolarization QT variability index QT dynamic sudden cardiac death ventricular arrhythmias chronic heart failure aging Geriatrics RC952-954.6
spellingShingle	Cardiac repolarization QT variability index QT dynamic sudden cardiac death ventricular arrhythmias chronic heart failure aging Geriatrics RC952-954.6 Piccirillo G Moscucci F Pascucci M Pappadà MA D’Alessandro G Rossi P Quaglione R Di Barba D Barillà F Magrì D Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
description	Gianfranco Piccirillo,1 Federica Moscucci,1 Matteo Pascucci,1 Maria Antonella Pappadà,1 Gaetana D’Alessandro,1 Pietro Rossi,2 Raffaele Quaglione,1 Daniele Di Barba,1 Francesco Barillà,1 Damiano Magrì3 1Department of Cardiovascular, Respiratory, Nephrological and Geriatric Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy; 2Division of Cardiology, S. Giovanni Calabita Fatebenefratelli Hospital, Rome, Italy; 3Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, “Sapienza” University of Rome, Rome, Italy Background and purpose: QT and Tpeak-Tend (Te) intervals are associated with sudden cardiac death in patients with chronic heart failure (CHF). We studied age-dependent influence on short-term temporal dispersion of these two variables in patients with postischemic CHF. Method: We grouped 75 CHF and 53 healthy control subjects into three age subsets: ≤50 years, >50 years and ≤65 years, and >65 years. We then calculated the following indices: QT and Te variability index (QTVI and TeVI), the ratio between the short-term variability (STV) of QT or Te, and the STV of resting rate (RR) (QT/RR STV and Te/RR STV). Results: In all different age subgroups, patients with CHF showed a higher level of QTVI than age-matched control subjects (≤50 years: P < 0.0001; >50 years and ≤65 years: P < 0.05; >65 years: P <  0.05). Patients with CHF < 50 years old also had all repolarization variability indices higher than normal age-matched controls (TeVI, P < 0.05; QT/RR STV, P < 0.05; Te/RR STV, P < 0.05), whereas we did not find any difference between the two older classes of subjects. Both QTVI (r2: 0.178, P < 0.05) and TeVI (r2: 0.433, P < 0.001) were positively related to age in normal subjects, even if the first correlation was weaker than the second one. Conclusion: Our data showed that QTVI could be used in all ages to evaluate repolarization temporal liability, whereas the other indices are deeply influenced by age. Probably, the age-dependent increase in QTVI was more influenced by a reduction of RR variability reported in older normal subjects. Keywords: aging, QT variability, heart rate variability, chronic heart failure, sudden death
format	article
author	Piccirillo G Moscucci F Pascucci M Pappadà MA D’Alessandro G Rossi P Quaglione R Di Barba D Barillà F Magrì D
author_facet	Piccirillo G Moscucci F Pascucci M Pappadà MA D’Alessandro G Rossi P Quaglione R Di Barba D Barillà F Magrì D
author_sort	Piccirillo G
title	Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
title_short	Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
title_full	Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
title_fullStr	Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
title_full_unstemmed	Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
title_sort	influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b484901092594e50b430326eb64f61e1
work_keys_str_mv	AT piccirillog influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT moscuccif influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT pascuccim influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT pappadagravema influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT drsquoalessandrog influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT rossip influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT quaglioner influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT dibarbad influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT barillagravef influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization AT magrigraved influenceofagingandchronicheartfailureontemporaldispersionofmyocardialrepolarization
_version_	1718400190749081600

Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization

Ejemplares similares