Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191

A high number of serotypes makes vaccine development to group A Streptococcus (GAS) difficult. Here, the authors use a reverse vaccinology approach and identify SPy_2191 as conserved surface protein that inhibits GAS adhesion and invasion and induces cross-protective immunity in mice.

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Autores principales:	Pooja Sanduja, Manish Gupta, Vikas Kumar Somani, Vikas Yadav, Meenakshi Dua, Emanuel Hanski, Abhinay Sharma, Rakesh Bhatnagar, Atul Kumar Johri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4879414065146d8ab6a111a33a04c34
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spelling	oai:doaj.org-article:b4879414065146d8ab6a111a33a04c342021-12-02T18:37:05ZCross-serotype protection against group A Streptococcal infections induced by immunization with SPy_219110.1038/s41467-020-17299-x2041-1723https://doaj.org/article/b4879414065146d8ab6a111a33a04c342020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17299-xhttps://doaj.org/toc/2041-1723A high number of serotypes makes vaccine development to group A Streptococcus (GAS) difficult. Here, the authors use a reverse vaccinology approach and identify SPy_2191 as conserved surface protein that inhibits GAS adhesion and invasion and induces cross-protective immunity in mice.Pooja SandujaManish GuptaVikas Kumar SomaniVikas YadavMeenakshi DuaEmanuel HanskiAbhinay SharmaRakesh BhatnagarAtul Kumar JohriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pooja Sanduja Manish Gupta Vikas Kumar Somani Vikas Yadav Meenakshi Dua Emanuel Hanski Abhinay Sharma Rakesh Bhatnagar Atul Kumar Johri Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
description	A high number of serotypes makes vaccine development to group A Streptococcus (GAS) difficult. Here, the authors use a reverse vaccinology approach and identify SPy_2191 as conserved surface protein that inhibits GAS adhesion and invasion and induces cross-protective immunity in mice.
format	article
author	Pooja Sanduja Manish Gupta Vikas Kumar Somani Vikas Yadav Meenakshi Dua Emanuel Hanski Abhinay Sharma Rakesh Bhatnagar Atul Kumar Johri
author_facet	Pooja Sanduja Manish Gupta Vikas Kumar Somani Vikas Yadav Meenakshi Dua Emanuel Hanski Abhinay Sharma Rakesh Bhatnagar Atul Kumar Johri
author_sort	Pooja Sanduja
title	Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
title_short	Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
title_full	Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
title_fullStr	Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
title_full_unstemmed	Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
title_sort	cross-serotype protection against group a streptococcal infections induced by immunization with spy_2191
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4879414065146d8ab6a111a33a04c34
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Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191

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