Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.

<h4>Unlabelled</h4>Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at puber...

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Autores principales:	Signe Sloth Mogensen, Lise Aksglaede, Annette Mouritsen, Kaspar Sørensen, Katharina M Main, Peter Gideon, Anders Juul
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b489af0402b0475887cdcd0178307003
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spelling	oai:doaj.org-article:b489af0402b0475887cdcd01783070032021-11-18T07:30:22ZPathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.1932-620310.1371/journal.pone.0029829https://doaj.org/article/b489af0402b0475887cdcd01783070032012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253792/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed.<h4>Objective</h4>To evaluate the outcome of brain MRI in girls referred with early signs of puberty in relation to age at presentation as well as clinical and biochemical parameters.<h4>Method</h4>A single-center study of 229 consecutive girls with early or precocious puberty who had brain imaging performed. We evaluated medical history, clinical and biochemical factors, and four groups were defined based on the outcome of their MRI.<h4>Results</h4>Thirteen out of 208 (6.3%) girls with precocious puberty, but no other sign of CNS symptoms, had a pathological brain MRI. Importantly, all 13 girls were above 6 years of age, and 6 girls were even 8-9 years old. Twenty girls (9.6%) had incidental findings on brain MRI. Furthermore, 21 girls had known CNS pathology at time of evaluation. Basal LH was significantly higher in girls with newly diagnosed CNS pathology compared to girls with a non-pathological MRI (p = 0.025); no cut of value was found as values overlapped.<h4>Conclusion</h4>A high frequency of 6-8 year old girls with precocious puberty in our study had a pathological brain MRI, which could not be predicted from any clinical nor biochemical parameters. Thus, we believe that girls with precocious pubertal development of central origin before 8 years of age should continue to be examined by a brain MRI.Signe Sloth MogensenLise AksglaedeAnnette MouritsenKaspar SørensenKatharina M MainPeter GideonAnders JuulPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29829 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Signe Sloth Mogensen Lise Aksglaede Annette Mouritsen Kaspar Sørensen Katharina M Main Peter Gideon Anders Juul Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
description	<h4>Unlabelled</h4>Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed.<h4>Objective</h4>To evaluate the outcome of brain MRI in girls referred with early signs of puberty in relation to age at presentation as well as clinical and biochemical parameters.<h4>Method</h4>A single-center study of 229 consecutive girls with early or precocious puberty who had brain imaging performed. We evaluated medical history, clinical and biochemical factors, and four groups were defined based on the outcome of their MRI.<h4>Results</h4>Thirteen out of 208 (6.3%) girls with precocious puberty, but no other sign of CNS symptoms, had a pathological brain MRI. Importantly, all 13 girls were above 6 years of age, and 6 girls were even 8-9 years old. Twenty girls (9.6%) had incidental findings on brain MRI. Furthermore, 21 girls had known CNS pathology at time of evaluation. Basal LH was significantly higher in girls with newly diagnosed CNS pathology compared to girls with a non-pathological MRI (p = 0.025); no cut of value was found as values overlapped.<h4>Conclusion</h4>A high frequency of 6-8 year old girls with precocious puberty in our study had a pathological brain MRI, which could not be predicted from any clinical nor biochemical parameters. Thus, we believe that girls with precocious pubertal development of central origin before 8 years of age should continue to be examined by a brain MRI.
format	article
author	Signe Sloth Mogensen Lise Aksglaede Annette Mouritsen Kaspar Sørensen Katharina M Main Peter Gideon Anders Juul
author_facet	Signe Sloth Mogensen Lise Aksglaede Annette Mouritsen Kaspar Sørensen Katharina M Main Peter Gideon Anders Juul
author_sort	Signe Sloth Mogensen
title	Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
title_short	Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
title_full	Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
title_fullStr	Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
title_full_unstemmed	Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
title_sort	pathological and incidental findings on brain mri in a single-center study of 229 consecutive girls with early or precocious puberty.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b489af0402b0475887cdcd0178307003
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Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.

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